Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | TAF1 | P21675 | 1/20 | 0.36 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19502748 | 1.00 | HTT (0.43) | HTTCCR5ALDH1A1LMNAKDM4E | |
| SCHEMBL800697 | 0.85 | HTT (0.45) | HTTCCR5ALDH1A1LMNAKDM4E | |
| SCHEMBL19882800 | 0.81 | ALDH1A1 (0.40) | CCR5ALDH1A1DPP4 | |
| SCHEMBL5498956 | 0.79 | FAAH (0.42) | ALDH1A1 | |
| SCHEMBL12022268 | 0.77 | ALDH1A1 (0.48) | ALDH1A1LMNAKDM4EKMT2AHTR2A | |
| SCHEMBL7979611 | 0.77 | ALDH1A1 (0.48) | ALDH1A1LMNAKDM4EKMT2AHTR2A | |
| SCHEMBL8191420 | 0.77 | HTT (0.43) | HTTCCR5ALDH1A1LMNAKDM4E | |
| SCHEMBL14155233 | 0.77 | HTT (0.43) | HTTCCR5ALDH1A1LMNAKDM4E | |
| SCHEMBL15029872 | 0.77 | GAA (0.51) | HTTALDH1A1LMNAKDM4EKMT2A | |
| SCHEMBL13808539 | 0.76 | HTT (0.42) | HTTCCR5ALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464273-B9 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-10-21 | — | — | EP | disclosed |
| EP-3464273-B1 | IMIDAZOLONE COMPOUNDS AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | CHIESI FARM SPA (IT) | 2020-04-08 | — | — | EP | disclosed |
| EP-3464268-B1 | NOVEL COMPOUNDS | CHIESI FARM SPA (IT) | 2020-03-11 | — | — | EP | disclosed |
| EP-2604601-A1 | HETERO RING COMPOUND | Astellas Pharma Inc. (JP) | 2013-06-19 | — | — | EP | disclosed |