Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504673 | 1.00 | ADAM17 (0.45) | ADAM17ADAM10MMP3ADAM9CA12 | |
| SCHEMBL995014 | 0.89 | ADAM17 (0.43) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL995012 | 0.89 | ADAM17 (0.43) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL995255 | 0.89 | ADAM17 (0.43) | ADAM17ADAM10MMP3ADAM9MMP2 | |
| SCHEMBL2681098 | 0.84 | L3MBTL1 (0.40) | CA12CA14ALDH1A1 | |
| SCHEMBL10079851 | 0.83 | L3MBTL1 (0.39) | CA12CA14ALDH1A1 | |
| SCHEMBL1503589 | 0.83 | L3MBTL1 (0.39) | CA12CA14ALDH1A1 | |
| SCHEMBL995159 | 0.82 | MEN1 (0.38) | CA12CA14ALDH1A1 | |
| SCHEMBL1504830 | 0.81 | KDM4E (0.48) | ADAM17ALDH1A1 | |
| SCHEMBL10313032 | 0.81 | MEN1 (0.36) | CA12CA14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |