Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | F13A1 | P00488 | 1/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.42 |
| ▸ | TGM1 | P22735 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504592 | 0.91 | KDM4E (0.52) | KDM4EADAM17LMNAGAAPKM | |
| SCHEMBL10276471 | 0.91 | KDM4E (0.52) | KDM4EADAM17LMNAGAAPKM | |
| SCHEMBL1504710 | 0.81 | ADAM17 (0.45) | ADAM17ALDH1A1 | |
| SCHEMBL1504673 | 0.81 | ADAM17 (0.45) | ADAM17ALDH1A1 | |
| SCHEMBL1504961 | 0.80 | KDM4E (0.56) | KDM4ELMNAGAAPKMNPSR1 | |
| SCHEMBL18289813 | 0.77 | GAA (0.60) | KDM4ELMNAGAAPKMALDH1A1 | |
| SCHEMBL2681098 | 0.76 | L3MBTL1 (0.40) | KDM4ELMNAGAAALDH1A1KMT2A | |
| SCHEMBL1503589 | 0.75 | L3MBTL1 (0.39) | LMNAGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL10079851 | 0.75 | L3MBTL1 (0.39) | LMNAGAAALDH1A1KMT2AMEN1 | |
| SCHEMBL5489489 | 0.75 | MAPK1 (0.50) | KDM4EGAAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033009-A1 | N- [2-HYDROXYCARBAMOYL-2- (PIPERAZINYL) ETHYL] BENZAMIDE COMPOUNDS, THEIR PREPARATION AND THEIR USE AS TACE INHIBITORS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-03-24 | — | — | WO | disclosed |