Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 16/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8004670 | 0.75 | FAAH (0.54) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL2681410 | 0.73 | FAAH (0.85) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL1728639 | 0.73 | FAAH (0.85) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL2681115 | 0.71 | FAAH (0.57) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL2681853 | 0.70 | FAAH (0.82) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL2682610 | 0.69 | FAAH (0.81) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL1002928 | 0.68 | FAAH (0.58) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL8002500 | 0.67 | FAAH (0.64) | FAAHCNR1ACHEPDE4APDE4B | |
| SCHEMBL301295 | 0.67 | SLC9A1 (0.60) | CNR1FFAR1 | |
| SCHEMBL3751420 | 0.67 | SLC9A1 (0.60) | CNR1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299824-B1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME (US) | 2013-06-19 | — | — | EP | disclosed |