Sugi Predict

Sugi Predict / Compounds / SCHEMBL301295

SCHEMBL301295

SCHEMBL301295

O=C(O)C1CC1c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC9A1 P19634 1/20 0.60
▸ FFAR1 O14842 7/20 0.59
▸ ALDH1A1 P00352 3/20 0.46
▸ HPGD P15428 2/20 0.46
▸ HDAC4 P56524 1/20 0.46
▸ LMNA P02545 1/20 0.46
▸ TP53 P04637 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ CYP1A2 P05177 2/20 0.44
▸ CYP3A4 P08684 2/20 0.44
▸ CYP2C9 P11712 2/20 0.44
▸ CYP2C19 P33261 2/20 0.44
▸ CYP2D6 P10635 1/20 0.44
▸ RECQL P46063 1/20 0.44
▸ POLB P06746 1/20 0.44
▸ HTT P42858 1/20 0.44
▸ RAB9A P51151 1/20 0.44
▸ CNR1 P21554 1/20 0.43
▸ HTR2A P28223 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13544388 1.00 SLC9A1 (0.60) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL4210867 1.00 SLC9A1 (0.60) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL3751420 1.00 SLC9A1 (0.60) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL7651885 1.00 SLC9A1 (0.60) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL6832060 1.00 SLC9A1 (0.60) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL805079 1.00 SLC9A1 (0.60) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL3119991 0.89 SLC9A1 (0.50) SLC9A1FFAR1ALDH1A1HPGDLMNA
SCHEMBL28574668 0.83 FFAR1 (0.50) SLC9A1FFAR1ALDH1A1HPGDHDAC4
SCHEMBL2835480 0.82 SLC9A1 (0.68) SLC9A1FFAR1ALDH1A1HPGDLMNA
SCHEMBL6130283 0.82 SLC9A1 (0.58) SLC9A1FFAR1ALDH1A1HPGDLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100292283-A1 NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2010-11-18 — — US claimed
EP-2225214-A1 NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS NeuroSearch AS (DK) 2010-09-08 — — EP claimed
WO-2009068557-A1 NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS NEUROSEARCH A/S (DK) 2009-06-04 — — WO claimed
US-20090036473-A1 NOVEL QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE NEUROSEARCH A/S (DK) 2009-02-05 — — US claimed
EP-1996560-A1 QUINAZOLINONES AND THEIR USE AS POTASSIUM CHANNELS ACTIVATORS NeuroSearch A/S (DK) 2008-12-03 — — EP claimed
WO-2007104717-A1 QUINAZOLINONES AND THEIR USE AS POTASSIUM CHANNELS ACTIVATORS NEUROSEARCH A/S (DK) 2007-09-20 — — WO claimed
EP-4709708-A1 NOVEL CARBOXAMIDE DERIVATIVES ANGELINI PHARMA S.P.A. (IT) 2026-03-18 — — EP disclosed
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors NURA BIO, INC. (US) 2025-09-02 — — US disclosed
WO-2024233603-A1 NOVEL CARBOXAMIDE DERIVATIVES ICAGEN, LLC (US) 2024-11-14 — — WO disclosed
US-11970481-B1 Substituted pyridine derivatives as SARM1 inhibitors NURA BIO, INC. (US) 2024-04-30 — — US disclosed
US-20240116901-A1 SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS NURA BIO, INC. 2024-04-11 — — US disclosed
CN-113896712-B Diamide compound containing cyclic amino acid 华东理工大学 2024-04-09 — — CN disclosed
WO-2024054811-A1 COMBINATION THERAPIES INCLUDING METAL CHANNEL ACTIVATORS BIOHAVEN THERAPEUTICS LTD. (VG) 2024-03-14 — — WO disclosed
US-5618941-A Benzenealkanoic acids for cardiovascular diseases PFIZER INC. (US) 1997-04-08 — — US disclosed
EP-0487095-B1 Pyridyl derivatives, medicines containing these compounds and processes for their preparation THOMAE GMBH DR K (DE) 1996-02-28 — — EP disclosed
EP-0662950-A1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES Pfizer Limited (GB) 1995-07-19 — — EP disclosed
CN-1087080-A The phenyl alkane acids class of treatment cardiovascular disorder PFIZER RES & DEV (IE) 1994-05-25 — — CN disclosed
WO-1994006761-A1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES PFIZER LIMITED (GB) 1994-03-31 — — WO disclosed
US-5286736-A Thromboxane antagonists and thromboxane synthetase inhibitors DR. KARL THOMAE GMBH (DE) 1994-02-15 — — US disclosed
EP-0487095-A1 Pyridyl derivatives, medicines containing these compounds and processes for their preparation Dr. Karl Thomae GmbH (DE) 1992-05-27 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12404265-B2 Substituted pyridine derivatives as SARM1 inhibitors SARM1, SARNP, ADRM1 SLC9A1 4531/4885FFAR1 4246/4885ALDH1A1 3991/4885
US-20090036473-A1 NOVEL QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE KCNK17, KCNN3, KCNA7 SLC9A1 263/4885FFAR1 2816/4885ALDH1A1 2372/4885
US-11970481-B1 Substituted pyridine derivatives as SARM1 inhibitors SARM1, SARNP, ADRM1 SLC9A1 4531/4885FFAR1 4246/4885ALDH1A1 3991/4885
US-20100292283-A1 NOVEL PHENYL-ACETAMIDE AND PHENYL-PROPIONAMIDE DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATORS KCNN2, KCNN1, KCNN3 SLC9A1 227/4885FFAR1 1519/4885ALDH1A1 1572/4885
US-20240116901-A1 SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS SARM1, SARNP, ADRM1 SLC9A1 4531/4885FFAR1 4246/4885ALDH1A1 3991/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.