Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.71 |
| ▸ | KDR | P35968 | 15/20 | 0.71 |
| ▸ | BRAF | P15056 | 2/20 | 0.60 |
| ▸ | AURKA | O14965 | 7/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 7/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | LCK | P06239 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | RET | P07949 | 1/20 | 0.60 |
| ▸ | MET | P08581 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.60 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.60 |
| ▸ | LTK | P29376 | 1/20 | 0.60 |
| ▸ | TTK | P33981 | 1/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | BTK | Q06187 | 1/20 | 0.60 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1504836 | 0.93 | KDR (0.71) | EGFRKDRBRAF | |
| SCHEMBL1504807 | 0.92 | EGFR (0.61) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL1505014 | 0.91 | EGFR (0.60) | EGFRKDRAURKAAURKBPDGFRB | |
| SCHEMBL3946804 | 0.90 | EGFR (0.78) | EGFRKDRAURKAAURKBPDGFRB | |
| SCHEMBL1504863 | 0.89 | KDR (0.58) | EGFRKDRBRAFFLT4 | |
| SCHEMBL3947459 | 0.89 | KDR (0.61) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL3946268 | 0.89 | AURKA (0.64) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL1504960 | 0.89 | EGFR (0.69) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL3953826 | 0.89 | AURKA (0.63) | EGFRKDRBRAFAURKAAURKB | |
| SCHEMBL2189126 | 0.89 | EGFR (0.70) | EGFRKDRAURKAAURKBPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033094-A1 | SCHEDULE OF ADMINISTRATION OF BENZAZOLE DERIVATIVES IN THE TREATMENT OF LEUKEMIAS | 4SC AG (DE) | 2011-03-24 | — | — | WO | claimed |