Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | ROS1 | P08922 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.42 |
| ▸ | STK3 | Q13188 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5452868 | 0.81 | TSHR (0.44) | ALKBH2EGLN1POLBALDH1A1KDM4E | |
| SCHEMBL3626705 | 0.73 | NOTUM (0.37) | RPS6KB1KDM4ECYP3A4CYP2C9SMN1; SMN2 | |
| SCHEMBL1907377 | 0.72 | SMN1; SMN2 (0.44) | ALKBH2EGLN1POLBALDH1A1KDM4E | |
| SCHEMBL2572281 | 0.72 | MARS1 (0.44) | ALKBH2EGLN1PLK4ROCK2RPS6KA5 | |
| SCHEMBL14688474 | 0.69 | SMN1; SMN2 (0.45) | ALKBH2EGLN1PLK4ROCK2RPS6KA5 | |
| SCHEMBL30398445 | 0.68 | ALKBH2 (0.47) | ALKBH2EGLN1PLK4ROCK2RPS6KA5 | |
| SCHEMBL14688583 | 0.68 | EGLN1 (0.75) | ALKBH2EGLN1CCNA2CDK2CCNA1 | |
| SCHEMBL29556787 | 0.68 | EGLN1 (0.75) | ALKBH2EGLN1CCNA2CDK2CCNA1 | |
| SCHEMBL3193063 | 0.67 | ALKBH2 (0.53) | ALKBH2EGLN1ALDH1A1KDM4ECYP3A4 | |
| SCHEMBL31133407 | 0.67 | ALKBH2 (0.53) | ALKBH2EGLN1ROCK1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526098-B1 | NITROGEN-CONTAINING HETEROARYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-07-11 | — | — | EP | claimed |
| US-8470820-B2 | Nitrogen-containing heteroaryl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | claimed |
| EP-2526098-B1 | NITROGEN-CONTAINING HETEROARYL DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-07-11 | — | — | EP | disclosed |
| US-8470820-B2 | Nitrogen-containing heteroaryl derivatives | HOFFMAN-LA ROCHE INC. (US) | 2013-06-25 | — | — | US | disclosed |