Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15048583 | 0.73 | ALKBH2 (0.46) | RPS6KB1SMN1; SMN2TSHRMAPK1CYP1A2 | |
| SCHEMBL15520764 | 0.72 | ALDH1A1 (0.48) | MAPTMEN1KMT2AKDM4E | |
| SCHEMBL1906385 | 0.72 | ADORA1 (0.42) | NOTUMADORA1MGLLMEN1KMT2A | |
| SCHEMBL3662997 | 0.72 | PARP1 (0.32) | — | |
| SCHEMBL15048515 | 0.72 | SCN9A (0.43) | NOTUMMAPK14ADORA1RPS6KB1SMN1; SMN2 | |
| SCHEMBL30398923 | 0.68 | NOTUM (0.55) | NOTUMMGLLSMN1; SMN2USP2MAPK1 | |
| SCHEMBL27835961 | 0.68 | ALKBH2 (0.45) | NOTUMMAPK14MAPT | |
| SCHEMBL1803333 | 0.66 | ALDH1A1 (0.39) | NOTUMADORA1KMT2ASMN1; SMN2ADORA3 | |
| SCHEMBL14699373 | 0.66 | ADORA2A (0.47) | ADORA1MEN1KMT2AADORA3USP2 | |
| SCHEMBL1718132 | 0.65 | PARP1 (0.48) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408767-B1 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | LUNDBECK & CO AS H (DK) | 2013-07-10 | — | — | EP | claimed |
| WO-2010108052-A2 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | H. LUNDBECK A/S (DK) | 2010-09-23 | — | — | WO | claimed |
| EP-2408767-B1 | AMIDE DERIVATIVES AS NEUROPEPTIDE Y5 RECEPTOR LIGANDS | LUNDBECK & CO AS H (DK) | 2013-07-10 | — | — | EP | disclosed |