Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | CDC7 | O00311 | 4/20 | 0.73 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15049177 | 0.86 | TRPM8 (0.76) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL17374877 | 0.86 | TRPM8 (0.75) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL8867589 | 0.85 | TRPM8 (1.00) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL15049120 | 0.85 | TRPM8 (0.74) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL28245760 | 0.85 | TRPM8 (0.73) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL15049096 | 0.85 | TRPM8 (1.00) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL6338322 | 0.84 | TRPM8 (1.00) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL17374866 | 0.84 | TRPM8 (1.00) | TRPM8MAPTMEN1KMT2A | |
| SCHEMBL15049591 | 0.83 | TRPM8 (0.71) | TRPM8MAPTMEN1KMT2ACDC7 | |
| SCHEMBL17317910 | 0.83 | TRPM8 (0.71) | TRPM8MAPTMEN1KMT2ACDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793883-B1 | TRPM8 ANTAGONISTS | DOMPE FARM SPA (IT) | 2018-04-18 | — | — | EP | claimed |
| US-9856246-B2 | TRPM8 antagonists | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2018-01-02 | — | — | US | claimed |
| US-20170129881-A1 | TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2017-05-11 | — | — | US | claimed |
| US-9585875-B2 | TRPM8 antagonists | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2017-03-07 | — | — | US | claimed |
| US-20140371276-A1 | TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2014-12-18 | — | — | US | claimed |
| EP-2793883-A1 | TRPM8 ANTAGONISTS | Dompe' S.p.A. (IT) | 2014-10-29 | — | — | EP | claimed |
| WO-2013092711-A1 | TRPM8 ANTAGONISTS | DOMPE' S.P.A. (IT) | 2013-06-27 | — | — | WO | claimed |
| EP-2606888-A1 | Trpm8 antagonists | Dompe' S.P.A. (IT) | 2013-06-26 | — | — | EP | claimed |
| CN-108699053-B | 4-hydroxy-2-phenyl-1, 3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | 东佩制药股份公司 | 2022-01-14 | — | — | CN | disclosed |
| US-11046662-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2021-06-29 | — | — | US | disclosed |
| CN-106660975-B | 2-aryl-4-hydroxy-1, 3-thiazole derivatives as TRPM 8-inhibitors for the treatment of neuralgia, pain, COPD and asthma | 东佩制药股份公司 | 2019-12-31 | — | — | CN | disclosed |
| EP-3394053-B1 | (4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL) METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPE FARM SPA (IT) | 2019-08-21 | — | — | EP | disclosed |
| US-20190106395-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-11 | — | — | US | disclosed |
| US-10246448-B2 | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-02 | — | — | US | disclosed |
| WO-2015197640-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPE' FARMACEUTICI S.P.A. (IT) | 2015-12-30 | — | — | WO | disclosed |
| US-20140371276-A1 | TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2014-12-18 | — | — | US | disclosed |
| CN-104220069-A | Trpm8 antagonists | DOMPE SPA | 2014-12-17 | — | — | CN | disclosed |
| EP-2793883-A1 | TRPM8 ANTAGONISTS | Dompe' S.p.A. (IT) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013092711-A1 | TRPM8 ANTAGONISTS | DOMPE' S.P.A. (IT) | 2013-06-27 | — | — | WO | disclosed |
| EP-2606888-A1 | Trpm8 antagonists | Dompe' S.P.A. (IT) | 2013-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170129881-A1 | TRPM8 ANTAGONISTS | TRPM8, TRPM7, TRPM5 | TRPM8 1/4885MAPT 282/4885MEN1 1269/4885 |
| US-20140371276-A1 | TRPM8 ANTAGONISTS | TRPM8, TRPM7, TRPV1 | TRPM8 1/4885MAPT 293/4885MEN1 1013/4885 |
| US-20190106395-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | TRPM8, TRPV1, TRPM7 | TRPM8 1/4885MAPT 468/4885MEN1 2385/4885 |
| US-11046662-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | TRPM8, TRPV1, TRPM7 | TRPM8 1/4885MAPT 468/4885MEN1 2692/4885 |
| US-10246448-B2 | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | TRPM8, TRPM5, TRPM4 | TRPM8 1/4885MAPT 608/4885MEN1 1450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.