Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 12/20 | 0.75 |
| ▸ | CDC7 | O00311 | 5/20 | 0.65 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17374813 | 0.86 | TRPM8 (0.72) | TRPM8CDC7DBF4MAPTLMNA | |
| SCHEMBL15048962 | 0.86 | TRPM8 (1.00) | TRPM8CDC7DBF4MAPTMEN1 | |
| SCHEMBL4163787 | 0.85 | CDC7 (0.79) | TRPM8CDC7DBF4MAPT | |
| SCHEMBL17374804 | 0.84 | TRPM8 (0.59) | TRPM8CDC7DBF4MAPTLMNA | |
| SCHEMBL17374797 | 0.84 | TRPM8 (0.70) | TRPM8CDC7DBF4MAPTKMT2A | |
| SCHEMBL15049533 | 0.84 | TRPM8 (0.66) | TRPM8CDC7DBF4MAPTMEN1 | |
| SCHEMBL17374911 | 0.84 | TRPM8 (0.73) | TRPM8CDC7DBF4MAPTLMNA | |
| SCHEMBL17374882 | 0.83 | TRPM8 (0.58) | TRPM8CDC7DBF4MAPTLMNA | |
| SCHEMBL17374875 | 0.83 | TRPM8 (0.58) | TRPM8CDC7DBF4MAPTLMNA | |
| SCHEMBL17374903 | 0.83 | TRPM8 (0.57) | TRPM8CDC7DBF4MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699053-B | 4-hydroxy-2-phenyl-1, 3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | 东佩制药股份公司 | 2022-01-14 | — | — | CN | disclosed |
| US-11046662-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2021-06-29 | — | — | US | disclosed |
| CN-106660975-B | 2-aryl-4-hydroxy-1, 3-thiazole derivatives as TRPM 8-inhibitors for the treatment of neuralgia, pain, COPD and asthma | 东佩制药股份公司 | 2019-12-31 | — | — | CN | disclosed |
| EP-3394053-B1 | (4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL) METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPE FARM SPA (IT) | 2019-08-21 | — | — | EP | disclosed |
| US-20190106395-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-11 | — | — | US | disclosed |
| US-10246448-B2 | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-04-02 | — | — | US | disclosed |
| EP-3157918-B1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA. | DOMPE FARM SPA (IT) | 2019-03-27 | — | — | EP | disclosed |
| US-10196368-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2019-02-05 | — | — | US | disclosed |
| US-20180319785-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2018-11-08 | — | — | US | disclosed |
| EP-3394053-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | Dompé farmaceutici S.p.A. (IT) | 2018-10-31 | — | — | EP | disclosed |
| US-20170190678-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2017-07-06 | — | — | US | disclosed |
| WO-2017108632-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | DOMPE' FARMACEUTICI S.P.A. (IT) | 2017-06-29 | — | — | WO | disclosed |
| EP-3184524-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | Dompé farmaceutici S.p.A. (IT) | 2017-06-28 | — | — | EP | disclosed |
| EP-3157918-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | Dompé farmaceutici S.p.A. (IT) | 2017-04-26 | — | — | EP | disclosed |
| WO-2015197640-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | DOMPE' FARMACEUTICI S.P.A. (IT) | 2015-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180319785-A1 | 4-HYDROXY-2-PHENYL-1,3-THIAZOL-5-YL METHANONE DERIVATIVES AS TRPM8 ANTAGONISTS | TRPM8, TRPM5, TRPM4 | TRPM8 1/4885CDC7 2967/4885DBF4 4028/4885 |
| US-20190106395-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | TRPM8, TRPV1, TRPM7 | TRPM8 1/4885CDC7 2505/4885DBF4 3932/4885 |
| US-20170190678-A1 | 2-ARYL-4-HYDROXY-1,3-THIAZOLE DERIVATIVES USEFUL AS TRPM8-INHIBITORS IN TREATMENT OF NEURALGIA, PAIN, COPD AND ASTHMA | TRPM8, TRPV1, TRPM7 | TRPM8 1/4885CDC7 2505/4885DBF4 3932/4885 |
| US-11046662-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | TRPM8, TRPV1, TRPM7 | TRPM8 1/4885CDC7 2481/4885DBF4 3899/4885 |
| US-10246448-B2 | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as TRPM8 antagonists | TRPM8, TRPM5, TRPM4 | TRPM8 1/4885CDC7 2967/4885DBF4 4028/4885 |
| US-10196368-B2 | 2-aryl-4-hydroxy-1,3-thiazole derivatives useful as TRPM8-inhibitors in treatment of neuralgia, pain, COPD and asthma | TRPM8, TRPV1, TRPM7 | TRPM8 1/4885CDC7 2505/4885DBF4 3932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.