Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP5 | Q13451 | 19/20 | 0.69 |
| ▸ | FKBP1A | P62942 | 7/20 | 0.68 |
| ▸ | FKBP4 | Q02790 | 7/20 | 0.68 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.66 |
| ▸ | HRH2 | P25021 | 1/20 | 0.66 |
| ▸ | HTR1D | P28221 | 1/20 | 0.66 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.66 |
| ▸ | FKBP2 | P26885 | 1/20 | 0.66 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.66 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18122793 | 1.00 | FKBP5 (0.69) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL24262242 | 1.00 | FKBP5 (0.69) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL29454405 | 1.00 | FKBP5 (0.69) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL15048833 | 1.00 | FKBP5 (0.69) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL18122830 | 0.98 | FKBP5 (0.67) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL19719609 | 0.98 | FKBP5 (0.67) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL18120744 | 0.90 | FKBP5 (0.56) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL18120701 | 0.90 | FKBP5 (0.62) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL18120711 | 0.88 | FKBP5 (0.55) | FKBP5FKBP1AFKBP4TMEM97HRH2 | |
| SCHEMBL18120741 | 0.84 | FKBP1A (0.60) | FKBP5FKBP1AFKBP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11253616-B2 | Small molecules for dual function positron emission tomography (PET) and cell suicide switches | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2022-02-22 | — | — | US | disclosed |
| US-20200316231-A1 | Compositions And Methods For Imaging Immune Cells | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2020-10-08 | — | — | US | disclosed |
| EP-3030556-B1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | UNIV DARMSTADT TECH (DE) | 2019-10-30 | — | — | EP | disclosed |
| EP-3030556-B1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | UNIV DARMSTADT TECH (DE) | 2019-10-30 | — | — | EP | disclosed |
| US-10246413-B2 | Selective FKBP51 ligands for treatment of psychiatric disorders | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2019-04-02 | — | — | US | disclosed |
| US-20190070321-A1 | SMALL MOLECULES FOR DUAL FUNCTION POSITRON EMISSION TOMOGRAPHY (PET) AND CELL SUICIDE SWITCHES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2019-03-07 | — | — | US | disclosed |
| US-20180072667-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | HAUSCH, FELIX (DE) | 2018-03-15 | — | — | US | disclosed |
| US-20180072667-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | HAUSCH, FELIX (DE) | 2018-03-15 | — | — | US | disclosed |
| US-9845292-B2 | Selective FKBP51 ligands for treatment of psychiatric disorders | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-12-19 | — | — | US | disclosed |
| US-9845292-B2 | Selective FKBP51 ligands for treatment of psychiatric disorders | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-12-19 | — | — | US | disclosed |
| US-9845292-B2 | Selective FKBP51 ligands for treatment of psychiatric disorders | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2017-12-19 | — | — | US | disclosed |
| US-20160289184-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | HAUSCH, FELIX (DE) | 2016-10-06 | — | — | US | disclosed |
| US-20160289184-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | HAUSCH, FELIX (DE) | 2016-10-06 | — | — | US | disclosed |
| US-20160289184-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | HAUSCH, FELIX (DE) | 2016-10-06 | — | — | US | disclosed |
| EP-3030556-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften (DE) | 2016-06-15 | — | — | EP | disclosed |
| WO-2015039758-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2015-03-26 | — | — | WO | disclosed |
| EP-2794566-A1 | PIPECOLATE-DIKETOAMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013091900-A1 | PIPECOLATE-DIKETOAMIDES FOR TREATMENT OF PSYCHIATRIC DISORDERS | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607352-A1 | Pipecolate-diketoamides for treatment of psychiatric disorders | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2013-06-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200316231-A1 | Compositions And Methods For Imaging Immune Cells | CD47, PAICS, CD4 | FKBP5 4171/4885FKBP1A 3746/4885FKBP4 4355/4885 |
| US-11253616-B2 | Small molecules for dual function positron emission tomography (PET) and cell suicide switches | BID, PAICS, BAD | FKBP5 372/4885FKBP1A 442/4885FKBP4 579/4885 |
| US-20180072667-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | FKBP5, FKBP1A, FKBP3 | FKBP5 1/4885FKBP1A 2/4885FKBP4 5/4885 |
| US-20190070321-A1 | SMALL MOLECULES FOR DUAL FUNCTION POSITRON EMISSION TOMOGRAPHY (PET) AND CELL SUICIDE SWITCHES | BID, PAICS, BAD | FKBP5 372/4885FKBP1A 442/4885FKBP4 579/4885 |
| US-10246413-B2 | Selective FKBP51 ligands for treatment of psychiatric disorders | FKBP5, FKBP1A, FKBP3 | FKBP5 1/4885FKBP1A 2/4885FKBP4 5/4885 |
| US-20160289184-A1 | SELECTIVE FKBP51 LIGANDS FOR TREATMENT OF PSYCHIATRIC DISORDERS | FKBP5, FKBP1A, FKBP1B | FKBP5 1/4885FKBP1A 2/4885FKBP4 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.