Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | APAF1 | O14727 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GALK1 | P51570 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15055530 | 0.83 | MAPT (0.48) | AKT1ALDH1A1PIK3CAPIK3CBMEN1 | |
| SCHEMBL1505634 | 0.77 | PIK3CB (0.47) | AKT1ALDH1A1IKBKBPIK3CAPIK3CB | |
| SCHEMBL139120 | 0.76 | AKT1 (0.41) | AKT1ALDH1A1PIK3CAPIK3CBPKM | |
| SCHEMBL1281306 | 0.76 | NPC1 (0.45) | ALDH1A1MEN1KMT2AAPAF1NPC1 | |
| SCHEMBL15055502 | 0.75 | AKT1 (0.48) | AKT1ALDH1A1PIK3CAPIK3CBPKM | |
| SCHEMBL31541762 | 0.74 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2AAPAF1NPC1 | |
| SCHEMBL13336854 | 0.74 | KMT2A (0.57) | ALDH1A1PIK3CAPIK3CBCRHBPCRHR2 | |
| SCHEMBL25771504 | 0.74 | KMO (0.50) | AKT1ALDH1A1PIK3CAPIK3CBPKM | |
| SCHEMBL16166760 | 0.74 | SMN1; SMN2 (0.46) | ALDH1A1MEN1KMT2ANPC1RAB9A | |
| SCHEMBL593003 | 0.73 | PIK3CB (0.48) | AKT1ALDH1A1PIK3CAPIK3CBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906910-B2 | Imidazopyridine derivatives as PI3 kinase | GLAXOSMITHKLINE LLC (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906910-B2 | Imidazopyridine derivatives as PI3 kinase | GLAXOSMITHKLINE LLC (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906910-B2 | Imidazopyridine derivatives as PI3 kinase | GLAXOSMITHKLINE LLC (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | Glaxo Smith Kline LLC a corporation | 2014-10-30 | — | — | US | disclosed |
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | Glaxo Smith Kline LLC a corporation | 2014-10-30 | — | — | US | disclosed |
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | Glaxo Smith Kline LLC a corporation | 2014-10-30 | — | — | US | disclosed |
| WO-2013095761-A1 | IMIDAZOPYRIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013095761-A1 | IMIDAZOPYRIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | PIK3CD, PI4KA, PIK3CG | AKT1 49/4885ALDH1A1 2259/4885IKBKB 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.