Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | APAF1 | O14727 | 1/20 | 0.44 |
| ▸ | TDP2 | O95551 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.44 |
| ▸ | GALK1 | P51570 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632944 | 0.81 | ALDH1A1 (0.47) | AKT1ALDH1A1PIK3CAPIK3CBPIK3CD | |
| SCHEMBL15054593 | 0.75 | AKT1 (0.48) | AKT1ALDH1A1PIK3CAPIK3CBPIK3CD | |
| SCHEMBL13336854 | 0.73 | KMT2A (0.57) | ALDH1A1PIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL1281782 | 0.73 | MAPT (0.47) | AKT1ALDH1A1PIK3CAPIK3CBPIK3CD | |
| SCHEMBL15055530 | 0.72 | MAPT (0.48) | AKT1ALDH1A1PIK3CAPIK3CBPIK3CD | |
| SCHEMBL19367477 | 0.72 | PIK3CA (0.60) | AKT1ALDH1A1PIK3CAPIK3CBMEN1 | |
| SCHEMBL1633176 | 0.71 | ALDH1A1 (0.44) | AKT1ALDH1A1PIK3CAPIK3CBPIK3CD | |
| SCHEMBL27927981 | 0.70 | KMT2A (0.48) | ALDH1A1PIK3CAPIK3CBMEN1KMT2A | |
| SCHEMBL25771504 | 0.70 | KMO (0.50) | AKT1ALDH1A1PIK3CAPIK3CBMEN1 | |
| SCHEMBL145784 | 0.70 | JAK2 (0.42) | AKT1ALDH1A1PIK3CAPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8906910-B2 | Imidazopyridine derivatives as PI3 kinase | GLAXOSMITHKLINE LLC (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906910-B2 | Imidazopyridine derivatives as PI3 kinase | GLAXOSMITHKLINE LLC (US) | 2014-12-09 | — | — | US | disclosed |
| US-8906910-B2 | Imidazopyridine derivatives as PI3 kinase | GLAXOSMITHKLINE LLC (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | Glaxo Smith Kline LLC a corporation | 2014-10-30 | — | — | US | disclosed |
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | Glaxo Smith Kline LLC a corporation | 2014-10-30 | — | — | US | disclosed |
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | Glaxo Smith Kline LLC a corporation | 2014-10-30 | — | — | US | disclosed |
| WO-2013095761-A1 | IMIDAZOPYRIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013095761-A1 | IMIDAZOPYRIDINE DERIVATIVES AS PI3 KINASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323480-A1 | Imidazopyridine Derivatives As PI3 Kinase | PIK3CD, PI4KA, PIK3CG | AKT1 49/4885ALDH1A1 2259/4885PIK3CA 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.