SCHEMBL15054845

SCHEMBL15054845

COC(=O)C1(c2cccc([N+](=O)[O-])c2)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
ADRA1D P25100 4/20 0.45
ADRA1A P35348 4/20 0.45
ADRA1B P35368 3/20 0.45
ALDH1A1 P00352 2/20 0.45
SLC6A4 P31645 1/20 0.45
LMNA P02545 1/20 0.44
TSHR P16473 1/20 0.44
MEN1 O00255 4/20 0.44
KMT2A Q03164 4/20 0.44
MAPT P10636 3/20 0.44
HTT P42858 2/20 0.44
CHRNA1 P02708 1/20 0.44
CHRNG P07510 1/20 0.44
CHRNB1 P11230 1/20 0.44
CHRNB2 P17787 1/20 0.44
SLC6A2 P23975 1/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15054545 0.94 SLC6A4 (0.46) KDM1ASMN1; SMN2ADRA1DADRA1AADRA1B
SCHEMBL15054977 0.94 MEN1 (0.48) KDM1ASMN1; SMN2ADRA1DADRA1AADRA1B
SCHEMBL6679093 0.82 TP53 (0.51) KDM1ASMN1; SMN2ALDH1A1LMNATSHR
SCHEMBL1465773 0.82 MEN1 (0.54) ADRA1DADRA1AADRA1BLMNATSHR
SCHEMBL15271889 0.81 KDM1A (0.54) KDM1AALDH1A1LMNATSHRMEN1
SCHEMBL30105392 0.80 KDM1A (0.50) KDM1ASMN1; SMN2ALDH1A1LMNATSHR
SCHEMBL4859733 0.78 LMNA (0.46) SMN1; SMN2ALDH1A1LMNATSHRMEN1
SCHEMBL22070797 0.77 HDAC4 (0.59) ADRA1DADRA1AADRA1BSLC6A4MEN1
SCHEMBL13764638 0.77 OPRK1 (0.44) SLC6A4SLC6A2
SCHEMBL6676255 0.77 AKR1C1 (0.53) KDM1ASMN1; SMN2ALDH1A1LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2019003143-A1 MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2019-01-03 WO disclosed
WO-2013096151-A1 CHEMICAL COMPOUNDS GLAXOSMITHKLINE LLC (US) 2013-06-27 WO disclosed