Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054771 | 0.99 | HPGD (0.47) | HPGDLMNAAHRPTPN2PTPN1 | |
| SCHEMBL25407953 | 0.88 | LMNA (0.47) | HPGDLMNAAHRPTPN2PTPN1 | |
| SCHEMBL30508434 | 0.85 | GAA (0.44) | HPGDLMNAAHRPTPN2PTPN1 | |
| SCHEMBL25407125 | 0.85 | GAA (0.44) | HPGDLMNAAHRPTPN2PTPN1 | |
| SCHEMBL15054264 | 0.81 | CYP19A1 (0.46) | HPGDLMNAAHRPTPN2PTPN1 | |
| SCHEMBL21712104 | 0.80 | EPHX2 (0.58) | LMNAPTPN11EPHX2GAAMEN1 | |
| SCHEMBL17933974 | 0.80 | CA12 (0.54) | LMNAEPHX2SMN1; SMN2GAAMEN1 | |
| SCHEMBL419102 | 0.79 | ALOX5 (0.55) | LMNASMN1; SMN2GAAHTTMEN1 | |
| SCHEMBL17933968 | 0.78 | CA12 (0.56) | LMNAEPHX2GAAMEN1KMT2A | |
| SCHEMBL30057722 | 0.78 | EPHX2 (0.50) | LMNAEPHX2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096151-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2013-06-27 | — | — | WO | disclosed |