Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 14/20 | 0.38 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.38 |
| ▸ | SLC19A1 | P41440 | 1/20 | 0.38 |
| ▸ | SLC46A1 | Q96NT5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054326 | 0.92 | DHFR (0.46) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL17562254 | 0.77 | DHFR (0.46) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL17554357 | 0.77 | DHFR (0.46) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL17554406 | 0.77 | DHFR (0.46) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL17554417 | 0.77 | DHFR (0.46) | DHFRFOLR1SLC19A1SLC46A1 | |
| Pteroic Acid SCHEMBL245982 | 0.71 | DHFR (0.67) | DHFR | |
| SCHEMBL17554416 | 0.71 | DHFR (0.44) | DHFRFOLR1SLC19A1SLC46A1 | |
| Potassium Ion SCHEMBL17554403 | 0.71 | DHFR (0.44) | DHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL15055069 | 0.71 | NOS1 (0.35) | DHFR | |
| Pteroic Acid SCHEMBL16047869 | 0.70 | DHFR (0.66) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794610-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE | PLUS CHEMICALS SA (CH) | 2016-03-09 | — | — | EP | disclosed |
| EP-2794610-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE | Plus Chemicals SA (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013096800-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE | PLUS CHEMICALS S.A. (CH) | 2013-06-27 | — | — | WO | disclosed |