Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 7/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15054330 | 0.92 | DHFR (0.39) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL15055063 | 0.71 | DHFR (0.38) | DHFR | |
| SCHEMBL15527635 | 0.70 | DHFR (0.41) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL15053633 | 0.69 | DHFR (0.46) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL27990340 | 0.66 | ALDH1A1 (0.42) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL13529957 | 0.65 | DHFR (0.60) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| Pteroic Acid SCHEMBL245982 | 0.65 | DHFR (0.67) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| Pteroic Acid SCHEMBL16047869 | 0.64 | DHFR (0.66) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| Pteroic Acid SCHEMBL28022366 | 0.64 | DHFR (0.66) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| Pteroic Acid SCHEMBL27919717 | 0.64 | DHFR (0.66) | ALDH1A1HPGDHSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2794610-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE | Plus Chemicals SA (CH) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013096800-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING PRALATREXATE | PLUS CHEMICALS S.A. (CH) | 2013-06-27 | — | — | WO | disclosed |