SCHEMBL1505539

SCHEMBL1505539

O/N=C/c1ccc(Cl)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.58
GRIN2D O15399 2/20 0.54
GRIN3B O60391 2/20 0.54
GRIN1 Q05586 2/20 0.54
GRIN2A Q12879 2/20 0.54
GRIN2B Q13224 2/20 0.54
GRIN2C Q14957 2/20 0.54
GRIN3A Q8TCU5 2/20 0.54
KMT2A Q03164 4/20 0.52
ALDH1A1 P00352 4/20 0.47
KDM4E B2RXH2 2/20 0.47
TRPA1 O75762 1/20 0.47
AMY1A P0DUB6 1/20 0.47
GAA P10253 1/20 0.47
ACHE P22303 1/20 0.46
MEN1 O00255 3/20 0.46
RAB9A P51151 2/20 0.46
NPC1 O15118 1/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2161959 1.00 MAOB (0.58) MAOBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL1505540 1.00 MAOB (0.58) MAOBGRIN2DGRIN3BGRIN1GRIN2A
Hydrochloric Acid SCHEMBL27732134 0.97 MAOB (0.56) MAOBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL6159475 0.87 HTT (0.57) MAOBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL6159479 0.87 HTT (0.57) MAOBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL16945360 0.87 HTT (0.57) MAOBGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL4275687 0.86 KMT2A (0.64) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL5668373 0.86 KMT2A (0.64) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL4275683 0.86 KMT2A (0.64) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL27198359 0.86 KMT2A (0.64) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 239 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021117053-A1 AN IMPROVED PROCESS FOR PREPARATION OF PURE ALDOXIME DR. SILVIU PHARMACHEM PVT. LTD. (IN) 2021-06-17 WO claimed
CN-108484408-A A kind of preparation method of rubigan nitromethane 盐城师范学院 2018-09-04 CN claimed
CN-106458639-A Recirculated wet-coating booth water treatment agent and treatment method 伯东株式会社 2017-02-22 CN claimed
CN-102367230-B Method for synthesizing nitrile from aldoxime UNIV YANGZHOU 2013-09-18 CN claimed
CN-101717411-B Methyl-removal cantharidin derivative phosphate disodium salt and synthesis method and application thereof UNIV SHAOXING 2012-10-10 CN claimed
US-20030215929-A1 Rhodococcus gene encoding aldoxime dehydratase E. I. DU PONT DE NEMOURS AND COMPANY 2003-11-20 US claimed
WO-1998005630-A1 PROCESS FOR THE PREPARATION OF ORGANIC NITRILES ALLIEDSIGNAL INC. (US) 1998-02-12 WO claimed
US-12637426-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors MISSION THERAPEUTICS LIMITED (GB) 2026-05-26 US disclosed
EP-4644375-A1 SUBSTITUTED HYDROQUINOLINES FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME Molius Saglik Teknolojileri Anonim Sirketi (TR) 2025-11-05 EP disclosed
US-20250145594-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2025-05-08 US disclosed
CN-119930463-A Asymmetric catalytic synthesis method of oxime ether compound with high optical purity 南方科技大学 2025-05-06 CN disclosed
CN-115232083-B Substituted isoxazole ethylamine compound and preparation method and application thereof 沈阳中化农药化工研发有限公司 2025-01-24 CN disclosed
EP-3615525-B1 PYRROLE DERIVATIVES AS PLK1 INHIBITORS SENTINEL ONCOLOGY LTD (GB) 2024-12-25 EP disclosed
US-5114960-A Rheumatoid arthritis; antiinflammatory and antishock agents; gastrointestinal and respiratory system disorders HOFFMANN-LA ROCHE INC. (US) 1992-05-19 US disclosed
US-5114936-A Antipsychotic and analgesic agents HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-05-19 US disclosed
EP-0474012-A1 6,7-Dihydro-3-phenyl-1,2-benzisoxazol-4(5H)-ones and -ols, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-03-11 EP disclosed
EP-0409273-A2 Substituted isoxazole and isothiazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 1991-01-23 EP disclosed
US-4931456-A Fungicidal oxime nicotinates RHONE-POULENC AGROCHIMIE (FR) 1990-06-05 US disclosed
CN-1033048-A FUNGICIDAL OXIME NICOTINATES RHONE POULENC AGROCHIMIE (FR) 1989-05-24 CN disclosed
US-4581365-A Trichloroacryloyl oxime fungicides NIHON TOKUSHU NOYAKU SEIZO K.K. (JP) 1986-04-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250145594-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 MAOB 1447/4885GRIN2D 2749/4885GRIN3B 2767/4885
US-12637426-B2 1-cyano-pyrrolidine compounds as USP30 inhibitors USP30, USP1, USP10 MAOB 3007/4885GRIN2D 4501/4885GRIN3B 4258/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.