Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | GFER | P55789 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | FURIN | P09958 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159479 | 1.00 | HTT (0.57) | HTTGFERMAPK1KMT2AMAPT | |
| SCHEMBL16945360 | 1.00 | HTT (0.57) | HTTGFERMAPK1KMT2AMAPT | |
| SCHEMBL1505540 | 0.87 | MAOB (0.58) | HTTMAPK1KMT2AMAPTALDH1A1 | |
| SCHEMBL2161959 | 0.87 | MAOB (0.58) | HTTMAPK1KMT2AMAPTALDH1A1 | |
| SCHEMBL1505539 | 0.87 | MAOB (0.58) | HTTMAPK1KMT2AMAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL27732134 | 0.85 | MAOB (0.56) | HTTMAPK1KMT2AMAPTALDH1A1 | |
| SCHEMBL9219952 | 0.83 | ALDH1A1 (0.62) | HTTKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL9219950 | 0.83 | ALDH1A1 (0.62) | HTTKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL16945357 | 0.82 | RAB9A (0.59) | HTTGFERMAPK1KMT2AMAPT | |
| SCHEMBL5957960 | 0.82 | RAB9A (0.59) | HTTGFERMAPK1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2875029-B1 | 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS | MORASKI GARRETT (US) | 2021-11-10 | — | — | EP | disclosed |
| US-9670192-B2 | Substituted isoxazole derivatives | BASF SE (DE) | 2017-06-06 | — | — | US | disclosed |
| US-9605002-B2 | 5,5-heteroaromatic anti-infective compounds | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2997026-B1 | SUBSTITUTED ISOXAZOLE DERIVATIVES | BASF SE (DE) | 2017-03-15 | — | — | EP | disclosed |
| US-20160096829-A1 | Substituted Isoxazole Derivatives | BASF SE (DE) | 2016-04-07 | — | — | US | disclosed |
| US-20150210715-A1 | 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS | UNIVERSITY OF NOTRE DAME DU LAC | 2015-07-30 | — | — | US | disclosed |
| EP-2875029-A2 | 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS | Moraski, Garrett (US) | 2015-05-27 | — | — | EP | disclosed |
| WO-2014015167-A2 | 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2014-01-23 | — | — | WO | disclosed |
| US-6953789-B2 | Thiol compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-10-11 | — | — | US | disclosed |
| US-20040157894-A1 | Thiol compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-08-12 | — | — | US | disclosed |
| US-6699881-B2 | MATRIX METALLOPROTEASE INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2004-03-02 | — | — | US | disclosed |
| US-20030078253-A1 | Thiol compounds, their production and use | TAKEDA PHARMACEUTICAL COMPANY, LIMITED (JP) | 2003-04-24 | — | — | US | disclosed |
| US-6420415-B1 | Thiol compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1132379-A1 | NOVEL THIOL DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND UTILIZATION THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2001-09-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078253-A1 | Thiol compounds, their production and use | TST, QSOX1, SULT1E1 | HTT 1420/4885GFER 103/4885MAPK1 2637/4885 |
| US-20040157894-A1 | Thiol compounds, their production and use | TST, SULT1E1, QSOX1 | HTT 1459/4885GFER 133/4885MAPK1 2685/4885 |
| US-20160096829-A1 | Substituted Isoxazole Derivatives | COX4I1, CYP4X1, TBXA2R | HTT 2881/4885GFER 2149/4885MAPK1 3779/4885 |
| US-20150210715-A1 | 5,5-HETEROAROMATIC ANTI-INFECTIVE COMPOUNDS | API5, CASP5, IL5 | HTT 3043/4885GFER 2607/4885MAPK1 3237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.