Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.61 |
| ▸ | RAB9A | P51151 | 5/20 | 0.61 |
| ▸ | TP53 | P04637 | 3/20 | 0.61 |
| ▸ | PKM | P14618 | 5/20 | 0.60 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.58 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.58 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17664665 | 0.82 | KLK7 (0.89) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL7777752 | 0.80 | KLK7 (0.83) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL6263820 | 0.78 | NPC1 (0.83) | MAPTHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL8660366 | 0.78 | NPC1 (0.83) | MAPTHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL19250385 | 0.78 | KLK7 (0.81) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL15056631 | 0.78 | KLK7 (0.60) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL2536044 | 0.78 | LMNA (0.78) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL12698771 | 0.77 | SMN1; SMN2 (1.00) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL17660222 | 0.77 | KLK7 (0.78) | KLK7MAPTHTTPOLBSMN1; SMN2 | |
| SCHEMBL6816610 | 0.77 | KLK7 (0.71) | KLK7MAPTHTTPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013093508-A2 | WNT PATHWAY INHIBITORS | OSLO UNIVERSITY HOSPITAL HF (NO) | 2013-06-27 | — | — | WO | disclosed |
| WO-2013093508-A2 | WNT PATHWAY INHIBITORS | OSLO UNIVERSITY HOSPITAL HF (NO) | 2013-06-27 | — | — | WO | disclosed |