SCHEMBL15058493

SCHEMBL15058493

CC(C)N(C)C(=O)C(F)(F)Oc1cccc(F)c1

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ HPGD P15428 1/20 0.47
▸ KMT2A Q03164 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ ATM Q13315 1/20 0.39
▸ PPARG P37231 1/20 0.38
▸ PPARA Q07869 1/20 0.38
▸ HDAC8 Q9BY41 1/20 0.38
▸ MGLL Q99685 1/20 0.37
▸ CNR1 P21554 1/20 0.37
▸ CNR2 P34972 1/20 0.37
▸ RIPK1 Q13546 1/20 0.36
▸ OPRM1 P35372 1/20 0.36
▸ CETP P11597 2/20 0.36
▸ NPC1 O15118 1/20 0.36
▸ RAB9A P51151 1/20 0.36
▸ MRGPRX4 Q96LA9 1/20 0.35
▸ USP2 O75604 1/20 0.35
▸ MAOB P27338 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15057124 0.85 HPGD (0.45) HPGDKMT2APPARGPPARAMGLL
SCHEMBL15059092 0.79 RIPK1 (0.40) HPGDKMT2AMEN1PPARGPPARA
SCHEMBL23519098 0.76 PPARG (0.45) HPGDKMT2AMEN1ATMPPARG
SCHEMBL15545838 0.74 KCNN4 (0.50) HPGDKMT2AMEN1PPARGPPARA
SCHEMBL15076071 0.74 CETP (0.41) HPGDKMT2APPARGPPARAMGLL
SCHEMBL15546762 0.71 POLB (0.49) PPARGPPARAMRGPRX4
SCHEMBL8276072 0.70 HDAC8 (0.61) HDAC8
SCHEMBL14227143 0.68 CETP (0.45) HPGDKMT2AMEN1ATMPPARG
SCHEMBL3373353 0.68 PPARA (0.54) KMT2AMEN1PPARGPPARACNR1
SCHEMBL13412201 0.68 CES2 (0.53) HPGDKMT2AMEN1OPRM1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9518045-B2 Process for manufacturing benzoxazinones BASF SE (DE) 2016-12-13 — — US disclosed
US-9518045-B2 Process for manufacturing benzoxazinones BASF SE (DE) 2016-12-13 — — US disclosed
US-9518045-B2 Process for manufacturing benzoxazinones BASF SE (DE) 2016-12-13 — — US disclosed
EP-2885281-B1 CARBAMAT-BENZOXAZINONES USEFUL FOR PREPARING TRIAZIN-BENZOXAZINONES BASF SE (DE) 2016-12-07 — — EP disclosed
EP-2885281-B1 CARBAMAT-BENZOXAZINONES USEFUL FOR PREPARING TRIAZIN-BENZOXAZINONES BASF SE (DE) 2016-12-07 — — EP disclosed
EP-2794554-B1 PROCESS FOR MANUFACTURING ARYLOXYACETAMIDES BASF SE (DE) 2016-08-17 — — EP disclosed
EP-2794554-B1 PROCESS FOR MANUFACTURING ARYLOXYACETAMIDES BASF SE (DE) 2016-08-17 — — EP disclosed
EP-2885296-B1 PROCESS FOR MANUFACTURING BENZOXAZINONES BASF SE (DE) 2016-06-29 — — EP disclosed
EP-2885296-B1 PROCESS FOR MANUFACTURING BENZOXAZINONES BASF SE (DE) 2016-06-29 — — EP disclosed
US-9365495-B2 Process for manufacturing aryloxyacetamides BASF SE (DE) 2016-06-14 — — US disclosed
US-20150119572-A1 Process for Manufacturing Aryloxyacetamides BASF SE (DE) 2015-04-30 — — US disclosed
US-20150119572-A1 Process for Manufacturing Aryloxyacetamides BASF SE (DE) 2015-04-30 — — US disclosed
US-20150119572-A1 Process for Manufacturing Aryloxyacetamides BASF SE (DE) 2015-04-30 — — US disclosed
CN-104583186-A Carbamate-benzoxazinones BASF SE 2015-04-29 — — CN disclosed
CN-104583205-A Process for producing benzoxazinones BASF SE 2015-04-29 — — CN disclosed
EP-2794554-A1 PROCESS FOR MANUFACTURING ARYLOXYACETAMIDES BASF SE (DE) 2014-10-29 — — EP disclosed
WO-2014026928-A1 PROCESS FOR MANUFACTURING BENZOXAZINONES BASF SE (DE) 2014-02-20 — — WO disclosed
WO-2014026893-A1 CARBAMAT-BENZOXAZINONES BASF SE (DE) 2014-02-20 — — WO disclosed
WO-2013092850-A1 PROCESS FOR MANUFACTURING ARYLOXYACETAMIDES BASF SE (DE) 2013-06-27 — — WO disclosed
WO-2013092850-A1 PROCESS FOR MANUFACTURING ARYLOXYACETAMIDES BASF SE (DE) 2013-06-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150119572-A1 Process for Manufacturing Aryloxyacetamides AADAC, CYP2E1, CYP1A2 HPGD 302/4885KMT2A 793/4885MEN1 4829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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