Known targets — ChEMBL curated mechanism
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The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 6/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL5249319 | 0.89 | LMNA (0.75) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL2553942 | 0.89 | LMNA (0.75) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL7455556 | 0.89 | LMNA (0.75) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL8773344 | 0.89 | LMNA (0.75) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL6005529 | 0.89 | — | — | |
| Glycerin SCHEMBL29231 | 0.89 | — | — | |
| Glycerin SCHEMBL23630291 | 0.86 | LMNA (0.69) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL8003351 | 0.86 | LMNA (0.69) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL17256232 | 0.86 | LMNA (0.69) | LMNAALDH1A1TSHRTHRBTDP1 | |
| Glycerin SCHEMBL1793735 | 0.86 | LMNA (0.69) | LMNAALDH1A1TSHRTHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2793962-A1 | PROCESS FOR MODIFYING THE SURFACE MORPHOLOGY OF A MEDICAL DEVICE | Le, Dang Quang Svend (DK) | 2014-10-29 | — | — | EP | disclosed |
| WO-2013091662-A1 | PROCESS FOR MODIFYING THE SURFACE MORPHOLOGY OF A MEDICAL DEVICE | AARHUS UNIVERSITET (DK) | 2013-06-27 | — | — | WO | disclosed |