Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | XBP1 | P17861 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 2/20 | 0.42 |
| ▸ | CASP7 | P55210 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11015546 | 0.82 | ADORA2A (0.54) | HSD17B10BLM | |
| SCHEMBL10535017 | 0.82 | ADORA2A (0.49) | KMT2ATSHRMAPTHSD17B10MEN1 | |
| SCHEMBL15923525 | 0.81 | GAA (0.47) | GAAKMT2ATSHRNPSR1MAPT | |
| SCHEMBL295965 | 0.78 | POLB (0.66) | GAAKMT2ATSHRMAPTSMN1; SMN2 | |
| SCHEMBL28075470 | 0.76 | GAA (0.46) | GAAKMT2ATSHRNPSR1MAPT | |
| SCHEMBL8952650 | 0.76 | CYP2C19 (0.47) | GAAKMT2ATSHRNPSR1MAPT | |
| SCHEMBL59950 | 0.75 | ADORA2B (0.48) | GAAKMT2ATSHRMAPTALDH1A1 | |
| SCHEMBL18990843 | 0.74 | ALDH1A1 (0.46) | GAAKMT2ATSHRNPSR1MAPT | |
| SCHEMBL387339 | 0.73 | ALDH1A1 (0.54) | GAAKMT2ATSHRNPSR1MAPT | |
| SCHEMBL18990217 | 0.73 | GAA (0.49) | GAAKMT2ATSHRNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 912 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100184212-A1 | HUMAN EMBRYONIC STEM CELL DERIVED MESODERM-LIKE EPITHELIUM TRANSITIONS TO MESENCHYMAL PROGENITOR CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC., THE | 2010-07-22 | — | — | US | claimed |
| US-20090028830-A1 | Preparation of multipotent stem cells and the use thereof | LIU YUNG-HSIANG | 2009-01-29 | — | — | US | claimed |
| WO-2008150498-A1 | HUMAN EMBRYONIC STEM CELL DERIVED MESODERM-LIKE EPITHELIUM TRANSITIONS TO MESENCHYMAL PROGENITOR CELLS | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION INC. (US) | 2008-12-11 | — | — | WO | claimed |
| CN-101085983-A | Autologous stem cell, target cell transformed therefrom and its uses | YONGXIANG LIU (CN) | 2007-12-12 | — | — | CN | claimed |
| EP-0954565-B1 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | OSIRIS THERAPEUTICS INC (US) | 2006-10-11 | — | — | EP | claimed |
| EP-1659172-A1 | Adipogenic differentiation of human mesenchymal stem cells | Osiris Therapeutics, Inc. (US) | 2006-05-24 | — | — | EP | claimed |
| US-20050192349-A1 | Isolation of the peroxisome proliferation-activated receptor-gamma (PPARgamma) ligand and methods of use thereof | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2005-09-01 | — | — | US | claimed |
| WO-2004097009-A2 | METHOD TO IDENTIFY AGENTS THAT ACTIVATE OR INHIBIT IKKi | NOVARTIS AG (CH) | 2004-11-11 | — | — | WO | claimed |
| WO-2004001052-A1 | ISOLATION OF THE PEROXISOME PROLIFERATION-ACTIVATED RECEPTOR-GAMMA (PPARη) LIGAND AND METHODS OF USE THEREOF | BETH ISRAEL DEACONESS MEDICAL CENTER, INC. (US) | 2003-12-31 | — | — | WO | claimed |
| EP-0954565-A4 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | OSIRIS THERAPEUTICS INC (US) | 2002-09-18 | — | — | EP | claimed |
| US-6322784-B1 | GLUCOCORTICOID, A COMPOUND WHICH STIMULATES CAMP PRODUCTION AND COMPOUND WHICH UPREGULATES PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR .GAMMA. EXPRESSION | OSIRIS THERAPEUTICS, INC. | 2001-11-27 | — | — | US | claimed |
| EP-0954565-A1 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | Osiris Therapeutics, Inc. (US) | 1999-11-10 | — | — | EP | claimed |
| US-5827740-A | Adipogenic differentiation of human mesenchymal stem cells | OSIRIS THERAPEUTICS, INC. (US) | 1998-10-27 | — | — | US | claimed |
| EP-0403139-B1 | Cell culture sytems and media | ORGANOGENESIS INC (US) | 1998-08-12 | — | — | EP | claimed |
| WO-1998004682-A1 | ADIPOGENIC DIFFERENTIATION OF HUMAN MESENCHYMAL STEM CELLS | OSIRIS THERAPEUTICS, INC. (US) | 1998-02-05 | — | — | WO | claimed |
| US-5712163-A | Chemically defined cell culture media and system and methods for use, particularly for culturing epithelial cells | ORGANOGENESIS, INC. (US) | 1998-01-27 | — | — | US | claimed |
| EP-0403139-A1 | Cell culture sytems and media | ORGANOGENESIS INC. (US) | 1990-12-19 | — | — | EP | claimed |
| US-4456687-A | CULTURES; CYCLIC ADENOSINE-3'-PHOSPHATE STIMULANTS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 1984-06-26 | — | — | US | claimed |
| US-20260076966-A1 | METHOD OF INHIBITING TREM-1 | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) | 2026-03-19 | — | — | US | disclosed |
| WO-1981001416-A1 | TRANSPLANTABLE SHEETS OF LIVING KERATINOUS TISSUE | MASSACHUSETTS INST TECHNOLOGY (US) | 1981-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260076966-A1 | METHOD OF INHIBITING TREM-1 | NR5A1, NR3C1, NR1H3 | GAA 4882/4885KMT2A 3956/4885TSHR 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.