Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.46 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13017071 | 0.82 | L3MBTL1 (0.44) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL14326968 | 0.80 | L3MBTL1 (0.51) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL19192553 | 0.77 | RAB9A (0.49) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL29328927 | 0.77 | RAB9A (0.49) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL23176353 | 0.76 | L3MBTL1 (0.48) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL16866011 | 0.72 | L3MBTL1 (0.44) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL22359675 | 0.69 | LOXL2 (0.40) | RAB9AMAPTNPC1SMN1; SMN2TP53 | |
| SCHEMBL13062939 | 0.68 | RECQL (0.49) | RAB9AMAPTNPC1SMN1; SMN2KMT2A | |
| SCHEMBL20274443 | 0.68 | RAB9A (0.51) | RAB9AMAPTNPC1SMN1; SMN2TP53 | |
| SCHEMBL16361384 | 0.66 | KMT2A (0.41) | L3MBTL1RAB9AMAPTNPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |