Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 4/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | USP1 | O94782 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL266175 | 0.86 | RORC (0.54) | ALOX5APFEN1CYP11B1CYP11B2RORC | |
| SCHEMBL13017143 | 0.85 | ALOX5AP (0.45) | ALOX5APFEN1CYP11B1CYP11B2RORC | |
| SCHEMBL15060597 | 0.81 | SCN9A (0.49) | ALOX5APFEN1UGCGSCN9A | |
| SCHEMBL15060623 | 0.81 | CYP3A4 (0.44) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15060601 | 0.75 | CYP11B1 (0.59) | ALOX5APFEN1CYP11B1CYP11B2NPC1 | |
| SCHEMBL12206594 | 0.74 | KDM1A (0.56) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL12524836 | 0.73 | L3MBTL1 (0.53) | SCN9ASMN1; SMN2CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16801759 | 0.73 | NPC1 (0.44) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14200502 | 0.72 | GAA (0.43) | CYP11B1CYP11B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13771808 | 0.72 | CYP11B1 (0.57) | ALOX5APFEN1CYP11B1CYP11B2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8471024-B2 | Tetrahydrofuropyridones | MERCK SHARP & DOHME, CORP. (US) | 2013-06-25 | — | — | US | disclosed |