Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.65 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.49 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.49 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.48 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.48 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23642694 | 0.84 | MAOB (0.67) | MAOBPARP15PARP10PARP14LPAR1 | |
| SCHEMBL28558238 | 0.82 | MAOB (0.68) | MAOBPARP15PARP10PARP14LPAR1 | |
| SCHEMBL5537147 | 0.80 | LTA4H (0.66) | MAOBMGLLLTA4HEPHX2 | |
| SCHEMBL863377 | 0.79 | TAAR1 (0.54) | MAOB | |
| SCHEMBL15061351 | 0.79 | MAOB (0.59) | MAOBPARP10MGLLLTA4HEPHX2 | |
| SCHEMBL28570119 | 0.79 | MAOB (0.63) | MAOBPARP15PARP10PARP14LPAR1 | |
| SCHEMBL5539557 | 0.79 | LTA4H (0.68) | MAOBMGLLLTA4HEPHX2 | |
| SCHEMBL9097927 | 0.78 | TAAR1 (0.56) | MAOB | |
| SCHEMBL15061376 | 0.77 | MAOB (0.68) | MAOBPARP10MGLLSCN9A | |
| SCHEMBL28548848 | 0.75 | MAOB (0.67) | MAOBPARP15PARP10PARP14LPAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | claimed |