Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463660 | 0.78 | SLC9A1 (0.57) | RAB9ANPC1MAPTSLC9A1TDP1 | |
| SCHEMBL1744970 | 0.78 | EGLN3 (0.58) | PLA2G4ARAB9ANPC1MAPT | |
| SCHEMBL17125454 | 0.76 | RAB9A (0.55) | RAB9ANPC1MAPTSLC9A1GRM2 | |
| SCHEMBL7377696 | 0.76 | MAPT (0.46) | PLA2G4ARAB9ANPC1MAPTSLC9A1 | |
| SCHEMBL6743169 | 0.73 | TSHR (0.51) | RAB9ANPC1MAPTSLC9A1TDP1 | |
| SCHEMBL730645 | 0.71 | SLC9A1 (0.70) | RAB9ANPC1MAPTSLC9A1TDP1 | |
| SCHEMBL28967756 | 0.70 | SLC9A1 (0.65) | PLA2G4ARAB9ANPC1MAPTSLC9A1 | |
| SCHEMBL30179307 | 0.70 | SLC9A1 (0.65) | PLA2G4ARAB9ANPC1MAPTSLC9A1 | |
| SCHEMBL3026641 | 0.70 | FFAR1 (0.62) | RAB9ANPC1TDP1 | |
| SCHEMBL3651402 | 0.69 | MAPT (0.61) | PLA2G4ARAB9ANPC1MAPTSLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476302-B2 | α-ketoamide derivatives useful endothelial lipase inhibitors | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-07-02 | — | — | US | claimed |