Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3463660 | 0.87 | SLC9A1 (0.57) | TSHRSLC9A1GRM2RAB9AMEN1 | |
| SCHEMBL7245160 | 0.84 | SLC9A1 (0.46) | TSHRGLASLC9A1GRM2RAB9A | |
| SCHEMBL17125454 | 0.82 | RAB9A (0.55) | TSHRSLC9A1GRM2RAB9AMEN1 | |
| SCHEMBL7377696 | 0.76 | MAPT (0.46) | TSHRSLC9A1GRM2RAB9ANPC1 | |
| SCHEMBL2490707 | 0.75 | RAB9A (0.50) | TSHRSLC9A1GRM2RAB9AMEN1 | |
| SCHEMBL4056785 | 0.74 | L3MBTL1 (0.55) | TSHRMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL5017651 | 0.74 | SLC9A1 (0.59) | TSHRGLASLC9A1GRM2RAB9A | |
| SCHEMBL12001037 | 0.74 | SLC9A1 (0.59) | TSHRGLASLC9A1GRM2RAB9A | |
| SCHEMBL2488643 | 0.74 | SLC9A1 (0.65) | TSHRGLASLC9A1GRM2RAB9A | |
| SCHEMBL29479886 | 0.74 | SLC9A1 (0.65) | TSHRGLASLC9A1GRM2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6689771-B2 | TREATMENT OF RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, PERIODONTITIS, GINGIVITIS, CORNEAL ULCERATION, SOLID TUMOR GROWTH | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-02-10 | — | — | US | disclosed |
| US-6610731-B2 | Antiinflammatory | BRISTOL-MYERS SQUIBB COMPANY | 2003-08-26 | — | — | US | disclosed |
| US-6403632-B1 | CYCLIC AMIDE DERIVATIVE | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2002-06-11 | — | — | US | disclosed |
| CN-1272841-A | Novel lactam metalloprotease inhibitors | DU PONT PHARM CO (US) | 2000-11-08 | — | — | CN | disclosed |