Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.33 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | PGR | P06401 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15060784 | 0.88 | PDE5A (0.37) | PDE5AALDH1A1KDM4EHSD17B10MAPK14 | |
| SCHEMBL12210495 | 0.87 | KDM4E (0.38) | PDE5AALDH1A1KDM4EHSD17B10MAPK14 | |
| SCHEMBL13273928 | 0.86 | HSP90AA1 (0.37) | PDE5AALDH1A1KDM4EHSD17B10MAPK14 | |
| SCHEMBL18404505 | 0.80 | POLB (0.35) | PDE5AALDH1A1KDM4EMAPK14HSP90AA1 | |
| SCHEMBL2489329 | 0.77 | HDAC8 (0.38) | ALDH1A1L3MBTL1HDAC11MEN1KMT2A | |
| SCHEMBL2489326 | 0.77 | SCN9A (0.39) | ALDH1A1L3MBTL1HDAC11 | |
| SCHEMBL13273917 | 0.76 | PPARG (0.41) | PDE5AALDH1A1L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL12210252 | 0.76 | KDM4E (0.35) | PDE5AALDH1A1L3MBTL1KDM4EHSD17B10 | |
| SCHEMBL15060795 | 0.74 | MTNR1A (0.34) | PDE5AKDM4EHSD17B10HSP90AA1MEN1 | |
| SCHEMBL15060788 | 0.74 | KDM4E (0.37) | PDE5AALDH1A1KDM4EHSD17B10MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303535-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | Sumitomo Pharma Co., Ltd. (JP) | 2013-11-14 | — | — | US | disclosed |
| US-8471038-B2 | Bicyclic heterocyclic compound | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2013-06-25 | — | — | US | disclosed |
| US-20110294804-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110294804-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | OPRL1, SCN1B, OPRD1 | PDE5A 1986/4885ALDH1A1 1411/4885L3MBTL1 183/4885 |
| US-20130303535-A1 | NOVEL BICYCLIC HETEROCYCLIC COMPOUND | OPRL1, SCN1B, OPRD1 | PDE5A 1986/4885ALDH1A1 1411/4885L3MBTL1 183/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.