SCHEMBL15061820

SCHEMBL15061820

CCCOC1CC(n2cc(C#CCNC(=O)C(F)(F)F)c(=O)[nH]c2=O)OC1CO

nearest known ligand 0.53

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
RNASE1 P07998 1/20 0.44
LMNA P02545 1/20 0.43
ALOX12 P18054 1/20 0.43
ADRA1A P35348 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
TK2 O00142 2/20 0.42
TK1 P04183 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4729467 0.91 RNASE1 (0.42) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL20810870 0.89 RNASE1 (0.43) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL20810838 0.89 RNASE1 (0.43) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL2619370 0.89 RNASE1 (0.43) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL1566423 0.89 RNASE1 (0.48) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL7221864 0.89 RNASE1 (0.48) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL18855351 0.89 RNASE1 (0.41) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL18866616 0.89 RNASE1 (0.41) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL2122161 0.89 RNASE1 (0.42) RNASE1LMNAALOX12ADRA1ASMN1; SMN2
SCHEMBL2122164 0.89 RNASE1 (0.42) RNASE1LMNAALOX12ADRA1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2607369-A1 Modified nucleotides for polynucleotide sequencing Illumina Cambridge Limited (GB) 2013-06-26 EP disclosed