Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | IKBKB | O14920 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CHUK | O15111 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RBP4 | P02753 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9903544 | 0.88 | EPHX2 (0.62) | EPHX2KMT2ANPC1RAB9ASCD | |
| SCHEMBL9013887 | 0.84 | IKBKB (0.49) | EPHX2KMT2AIKBKBCHUKNAMPT | |
| SCHEMBL30352887 | 0.83 | IKBKB (0.47) | EPHX2IKBKBTDP1CHUKSCD | |
| SCHEMBL28278842 | 0.82 | EPHX2 (0.57) | EPHX2KMT2ANPC1RAB9ASCD | |
| SCHEMBL17559489 | 0.82 | IKBKB (0.51) | EPHX2IKBKBTDP1CHUKNAMPT | |
| SCHEMBL21765007 | 0.82 | KDM1A (0.57) | EPHX2KMT2A | |
| SCHEMBL10608977 | 0.81 | EPHX2 (0.56) | EPHX2KMT2ANPC1RAB9ASCD | |
| SCHEMBL17955461 | 0.81 | RBP4 (0.67) | EPHX2IKBKBCHUKSCDNAMPT | |
| SCHEMBL31202927 | 0.80 | IKBKB (0.47) | KMT2AIKBKBTDP1CHUKRAB9A | |
| SCHEMBL13536484 | 0.80 | EPHX2 (0.55) | EPHX2KMT2ANPC1RAB9ASCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013091773-A1 | TETRAAZA-CYCLOPENTA[A]INDENYL AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS | MERCK PATENT GMBH (DE) | 2013-06-27 | — | — | WO | disclosed |
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |