Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18563146 | 0.86 | KDM4E (0.64) | KDM4EHTR7HTR1BDRD2DRD1 | |
| SCHEMBL22831334 | 0.84 | HTR7 (0.50) | KDM4EHTR7HTR1BDRD2DRD1 | |
| SCHEMBL14000157 | 0.82 | KDM4E (0.56) | KDM4EHTR7HTR1BALDH1A1SMN1; SMN2 | |
| SCHEMBL14647148 | 0.81 | HTR7 (0.65) | KDM4EHTR7HTR1BDRD2DRD1 | |
| SCHEMBL7524809 | 0.81 | KDM4E (0.53) | KDM4EHTR7HRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL13069271 | 0.80 | FFAR1 (0.47) | KDM4EFFAR1FFAR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL18773673 | 0.79 | KDM4E (0.52) | KDM4EHTR7HTR1BALDH1A1SMN1; SMN2 | |
| SCHEMBL4632018 | 0.79 | KDM4E (0.51) | KDM4EHTR7HTR1BDRD2DRD1 | |
| SCHEMBL17147252 | 0.79 | KDM4E (0.62) | KDM4EHTR7HTR1BDRD2DRD1 | |
| SCHEMBL14672453 | 0.79 | KDM4E (0.59) | KDM4EHTR7HTR1BDRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2607364-A1 | Tetraaza-cyclopenta[a]indenyl and their use as positive allosteric modulators | Ares Trading S.A. (CH) | 2013-06-26 | — | — | EP | disclosed |