Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | BACE1 | P56817 | 4/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CTSD | P07339 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL496196 | 0.87 | SCN9A (0.42) | SCN9ABACE1KLK5GPR119CTSS | |
| SCHEMBL496197 | 0.87 | SCN9A (0.42) | SCN9ABACE1KLK5GPR119CTSS | |
| SCHEMBL495863 | 0.84 | KLK5 (0.43) | SCN9AKLK5GPR119CTSSCTSK | |
| SCHEMBL495865 | 0.84 | KLK5 (0.43) | SCN9AKLK5GPR119CTSSCTSK | |
| SCHEMBL496081 | 0.82 | RIPK1 (0.41) | SCN9AKLK5GPR119CTSSCTSK | |
| SCHEMBL496083 | 0.82 | RIPK1 (0.41) | SCN9AKLK5GPR119CTSSCTSK | |
| SCHEMBL15062933 | 0.78 | KLK5 (0.59) | BACE1KLK5CTSSCTSKATM | |
| SCHEMBL10074464 | 0.77 | SCN9A (0.49) | SCN9AGPR119CTSSCTSKPTPN1 | |
| SCHEMBL6873438 | 0.76 | CTSK (0.47) | SCN9AGPR119CTSSCTSKPTPN1 | |
| SCHEMBL269147 | 0.75 | SCN9A (0.45) | SCN9AKLK5CTSSCTSKPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910317-B1 | 1-AMINO LINKED COMPOUNDS | LILLY CO ELI (US) | 2013-07-03 | — | — | EP | disclosed |