SCHEMBL15063186

SCHEMBL15063186

CN(C)C(=O)c1nc(N=NN)c[nH]1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MAP4K1 Q92918 1/20 0.31
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL497678 0.68
SCHEMBL25354296 0.66 CYP1A2 (0.43) KMT2A
SCHEMBL25354300 0.66 CYP1A2 (0.43) KMT2A
SCHEMBL31708528 0.64 CNR2 (0.32)
SCHEMBL1038218 0.60 ALDH1A1 (0.31)
SCHEMBL970408 0.60 NPC1 (0.49) MAP4K1KMT2A
SCHEMBL20570053 0.58 TRPM8 (0.34) KMT2A
SCHEMBL21632736 0.56 L3MBTL1 (0.42)
SCHEMBL21095492 0.56 MAP4K1 (0.36) MAP4K1KMT2A
SCHEMBL3013035 0.56 MALT1 (0.33) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240052428-A1 COMPOSITIONS AND METHODS FOR CHARACTERIZING LYMPHOMA AND RELATED CONDITIONS THE BROAD INSTITUTE, INC. (US) 2024-02-15 US disclosed
EP-4308733-A1 COMPOSITIONS AND METHODS FOR CHARACTERIZING LYMPHOMA AND RELATED CONDITIONS The Broad Institute, Inc. (US) 2024-01-24 EP disclosed
WO-2022197933-A9 COMPOSITIONS AND METHODS FOR CHARACTERIZING LYMPHOMA AND RELATED CONDITIONS THE BROAD INSTITUTE, INC. (US) 2023-06-08 WO disclosed
WO-2022197933-A1 COMPOSITIONS AND METHODS FOR CHARACTERIZING LYMPHOMA AND RELATED CONDITIONS THE BROAD INSTITUTE, INC. (US) 2022-09-22 WO disclosed
US-9091697-B2 Use of 2 anti-SPARC antibodies to predict response to chemotherapy for pancreatic adenocarcinoma ABRAXIS BIOSCIENCE, LLC (US) 2015-07-28 US disclosed
US-20130172261-A1 USE OF 2 ANTI-SPARC ANTIBODIES TO PREDICT RESPONSE TO CHEMOTHERAPY ABRAXIS BIOSCIENCE, LLC (US) 2013-07-04 US disclosed