Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.80 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1506434 | 1.00 | SLC6A4 (0.80) | SLC6A4SLC6A3POLBRAB9ACYP3A4 | |
| SCHEMBL2983151 | 0.79 | SLC6A3 (0.79) | SLC6A4SLC6A3 | |
| SCHEMBL1505936 | 0.78 | MEN1 (0.69) | SLC6A4SLC6A3SIGMAR1MEN1KMT2A | |
| SCHEMBL1476523 | 0.77 | SLC6A3 (0.65) | SLC6A4SLC6A3 | |
| SCHEMBL24321061 | 0.75 | MCHR1 (0.50) | SLC6A4SLC6A3POLBRAB9A | |
| SCHEMBL7381004 | 0.74 | DRD2 (0.67) | SIGMAR1 | |
| SCHEMBL9872315 | 0.74 | ALDH1A1 (0.52) | POLBMEN1KMT2A | |
| Bromide SCHEMBL15157969 | 0.73 | DRD2 (0.68) | SIGMAR1 | |
| SCHEMBL2989347 | 0.73 | SLC6A3 (0.66) | SLC6A4SLC6A3 | |
| SCHEMBL10070618 | 0.72 | KMT2A (0.62) | SLC6A4SLC6A3SIGMAR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2291378-A2 | N- AND O-SUBSTITUTED 4-Ý2-(DIPHENYLMETHOXY)-ETHYL¨-1-Ý(PHENYL)METHYL¨PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH | WAYNE STATE UNIVERSITY (US) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009094428-A2 | N- AND O-SUBSTITUTED 4-[2-(DIPHENYLMETHOXY)-ETHYL]-1-[(PHENYL)METHYL]PIPERIDINE ANALOGS AND METHODS OF TREATING CNS DISORDERS THEREWITH | WAYNE STATE UNIVERSITY (US) | 2009-07-30 | — | — | WO | disclosed |