Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | BLM | P54132 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.44 |
| ▸ | RECQL | P46063 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | CASP7 | P55210 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064902 | 0.85 | MAPT (0.47) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL15084267 | 0.84 | KDM4E (0.46) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL23162599 | 0.79 | ADORA2A (0.49) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL21460575 | 0.69 | TDP1 (0.46) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL929525 | 0.68 | ADORA2A (0.56) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL21704503 | 0.67 | HSP90AA1 (0.57) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL21460544 | 0.67 | KDM4E (0.47) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL22463752 | 0.67 | ADORA2A (0.72) | ADORA2AADORA1ADORA3 | |
| SCHEMBL1397084 | 0.66 | CYP1A2 (0.38) | ALDH1A1ALOX15TSHR | |
| SCHEMBL24900719 | 0.65 | CDK5 (0.48) | MEN1KMT2AALDH1A1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797897-B1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DOW AGROSCIENCES LLC (US) | 2017-02-01 | — | — | EP | disclosed |
| EP-2797897-B1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DOW AGROSCIENCES LLC (US) | 2017-02-01 | — | — | EP | disclosed |
| US-9216958-B2 | 2,6-dihalo-5-alkoxy-4-substituted-pyrimidines, pyrimidine-carbaldehydes, and methods of formation and use | DOW AGROSCIENCES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216958-B2 | 2,6-dihalo-5-alkoxy-4-substituted-pyrimidines, pyrimidine-carbaldehydes, and methods of formation and use | DOW AGROSCIENCES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216958-B2 | 2,6-dihalo-5-alkoxy-4-substituted-pyrimidines, pyrimidine-carbaldehydes, and methods of formation and use | DOW AGROSCIENCES LLC (US) | 2015-12-22 | — | — | US | disclosed |
| US-20150031883-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE-CARBALDEHYDES, AND METHODS OF FORMATION AND USE | CORTEVA AGRISCIENCE LLC | 2015-01-29 | — | — | US | disclosed |
| US-20150031883-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE-CARBALDEHYDES, AND METHODS OF FORMATION AND USE | CORTEVA AGRISCIENCE LLC | 2015-01-29 | — | — | US | disclosed |
| US-20150031883-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE-CARBALDEHYDES, AND METHODS OF FORMATION AND USE | CORTEVA AGRISCIENCE LLC | 2015-01-29 | — | — | US | disclosed |
| US-8877925-B2 | 2,6-dihalo-5-alkoxy-4-substituted-pyrimidines, pyrimidine-carbaldehydes, and methods of formation and use | DOW AGROSCIENCES, LLC. (US) | 2014-11-04 | — | — | US | disclosed |
| US-8877925-B2 | 2,6-dihalo-5-alkoxy-4-substituted-pyrimidines, pyrimidine-carbaldehydes, and methods of formation and use | DOW AGROSCIENCES, LLC. (US) | 2014-11-04 | — | — | US | disclosed |
| WO-2013102111-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DOW AGROSCIENCES LLC (US) | 2013-07-04 | — | — | WO | disclosed |
| US-20130172557-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DOW AGROSCIENCES LLC (US) | 2013-07-04 | — | — | US | disclosed |
| US-20130172557-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DOW AGROSCIENCES LLC (US) | 2013-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130172557-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE- CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DPYD, DDT, DCTD | MAPT 3654/4885MEN1 4628/4885KMT2A 1783/4885 |
| US-20150031883-A1 | 2,6-DIHALO-5-ALKOXY-4-SUBSTITUTED-PYRIMIDINES, PYRIMIDINE-CARBALDEHYDES, AND METHODS OF FORMATION AND USE | DPYD, DDT, DCTD | MAPT 3654/4885MEN1 4628/4885KMT2A 1783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.