Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | AIP | O00170 | 1/20 | 0.42 |
| ▸ | SGTA | O43765 | 1/20 | 0.42 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.42 |
| ▸ | STIP1 | P31948 | 1/20 | 0.42 |
| ▸ | PPP5C | P53041 | 1/20 | 0.42 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.42 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.42 |
| ▸ | FKBP8 | Q14318 | 1/20 | 0.42 |
| ▸ | TOMM34 | Q15785 | 1/20 | 0.42 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.42 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21704504 | 0.84 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1L3MBTL1ADORA2BCFTR | |
| SCHEMBL15084267 | 0.76 | KDM4E (0.46) | HSP90AA1HSP90AB1L3MBTL1ALDH1A1PKM | |
| SCHEMBL21032131 | 0.74 | KDM4E (0.45) | L3MBTL1ALDH1A1TSHRHPGDKDM4E | |
| SCHEMBL21704319 | 0.74 | L3MBTL1 (0.67) | HSP90AA1HSP90AB1L3MBTL1ADORA2BALDH1A1 | |
| SCHEMBL23204450 | 0.73 | ADORA2B (0.57) | HSP90AA1HSP90AB1L3MBTL1ADORA2BALDH1A1 | |
| SCHEMBL29623513 | 0.73 | ADORA2B (0.57) | HSP90AA1HSP90AB1L3MBTL1ADORA2BALDH1A1 | |
| SCHEMBL6167496 | 0.73 | CFTR (0.55) | HSP90AA1HSP90AB1L3MBTL1ADORA2BCFTR | |
| SCHEMBL21460575 | 0.71 | TDP1 (0.46) | HSP90AA1HSP90AB1L3MBTL1ADORA2BALDH1A1 | |
| SCHEMBL2466944 | 0.70 | CFTR (0.58) | HSP90AA1HSP90AB1L3MBTL1ADORA2BCFTR | |
| SCHEMBL21704463 | 0.70 | L3MBTL1 (0.64) | HSP90AA1HSP90AB1L3MBTL1ADORA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066413-B2 | Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2021-07-20 | — | — | US | disclosed |
| US-20200048270-A1 | AMINOPYRIMIDINE FIVE-MEMBERED HETEROCYCLIC COMPOUND, AND INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | GUANGZHOU MAXINOVEL PHARMACEUTICALS CO., LTD. (CN) | 2020-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200048270-A1 | AMINOPYRIMIDINE FIVE-MEMBERED HETEROCYCLIC COMPOUND, AND INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF | ADORA2A, ADORA2B, ADORA3 | HSP90AA1 4478/4885HSP90AB1 4463/4885L3MBTL1 4698/4885 |
| US-11066413-B2 | Aminopyrimidine five-membered heterocyclic compound, and intermediate, preparation method, pharmaceutical composition and application thereof | ADORA2A, ADORA2B, ADORA3 | HSP90AA1 4478/4885HSP90AB1 4463/4885L3MBTL1 4698/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.