Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 4/20 | 0.46 |
| ▸ | BLM | P54132 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21460544 | 0.86 | KDM4E (0.47) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL15084267 | 0.73 | KDM4E (0.46) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL15064902 | 0.71 | MAPT (0.47) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL21704503 | 0.71 | HSP90AA1 (0.57) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL11836181 | 0.70 | ADORA2A (0.52) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL929525 | 0.69 | ADORA2A (0.56) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL14002317 | 0.69 | ADORA2A (0.46) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL15065223 | 0.69 | MAPT (0.44) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL3682872 | 0.67 | MAPT (0.42) | TDP1KDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL13668446 | 0.67 | ADORA2A (0.69) | TDP1KDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683282-B2 | Multi-substituted pyrimidine derivatives with excellent kinase inhibitory activities | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2020-06-16 | — | — | US | disclosed |
| WO-2019198940-A1 | EXCELLENT KINASE INHIBITORY ACTIVITY-EXHIBITING PYRIMIDINE DERIVATIVE HAVING VARIOUS SUBSTITUENTS | 한국과학기술연구원 | 2019-10-17 | — | — | WO | disclosed |
| US-20190315726-A1 | MULTI-SUBSTITUTED PYRIMIDINE DERIVATIVES WITH EXCELLENT KINASE INHIBITORY ACTIVITIES | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2019-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683282-B2 | Multi-substituted pyrimidine derivatives with excellent kinase inhibitory activities | JAK1, NUAK1, JAK2 | TDP1 461/4885KDM4E 3422/4885ALDH1A1 4059/4885 |
| US-20190315726-A1 | MULTI-SUBSTITUTED PYRIMIDINE DERIVATIVES WITH EXCELLENT KINASE INHIBITORY ACTIVITIES | JAK1, NUAK1, JAK2 | TDP1 461/4885KDM4E 3422/4885ALDH1A1 4059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.