Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065242 | 0.85 | ALDH1A1 (0.34) | ALDH1A1MAPTSMN1; SMN2NPC1HTT | |
| SCHEMBL30078149 | 0.85 | ALDH1A1 (0.34) | ALDH1A1MAPTSMN1; SMN2NPC1HTT | |
| SCHEMBL21748419 | 0.81 | KDM4A (0.32) | PPARGERN1L3MBTL1HSD17B10 | |
| SCHEMBL15068350 | 0.80 | OXTR (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL30078196 | 0.80 | MAPT (0.38) | PPARGALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL15065234 | 0.80 | MAPT (0.38) | PPARGALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30078028 | 0.79 | TBXAS1 (0.38) | ALDH1A1MAPTSMN1; SMN2NPC1HTT | |
| SCHEMBL15064307 | 0.79 | TBXAS1 (0.38) | ALDH1A1MAPTSMN1; SMN2NPC1HTT | |
| SCHEMBL21748406 | 0.77 | DHODH (0.39) | PPARGALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30078116 | 0.76 | PSEN1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797597-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | Global Blood Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013102145-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |