SCHEMBL15066596

SCHEMBL15066596

c1ccc2cc(C(O[SiH2]c3cccc4ccccc34)c3ccc4ccccc4c3)ccc2c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
UGT2B7 P16662 1/20 0.39
AOC3 Q16853 2/20 0.36
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ATM Q13315 1/20 0.34
ALDH1A1 P00352 2/20 0.33
HSD17B10 Q99714 2/20 0.33
TSHR P16473 2/20 0.33
HIF1A Q16665 2/20 0.33
CYP2A6 P11509 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CYP1B1 Q16678 1/20 0.33
SLC6A2 P23975 4/20 0.33
SLC6A4 P31645 4/20 0.33
SLC6A3 Q01959 4/20 0.33
KCNH2 Q12809 3/20 0.33
NQO1 P15559 1/20 0.33
ADRA2A P08913 1/20 0.33
ADRA2B P18089 1/20 0.33
ADRA2C P18825 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15067861 0.83 SLC6A4 (0.37) ATMALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL17835374 0.73 CYP1A2 (0.39) MEN1KMT2AALDH1A1HSD17B10TSHR
SCHEMBL16487309 0.73 KDM4E (0.39) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL31519361 0.69 UGT2B7 (0.54) UGT2B7AOC3MEN1KMT2AATM
SCHEMBL31519358 0.69 UGT2B7 (0.54) UGT2B7AOC3MEN1KMT2AATM
SCHEMBL22661061 0.69 ADRA2A (0.36) AOC3ALDH1A1HSD17B10TSHRCYP2A6
SCHEMBL15302524 0.69 ALDH1A1 (0.32) ALDH1A1HSD17B10TSHRCYP2A6TDP1
SCHEMBL15066842 0.68 UGT2B7 (0.36) UGT2B7AOC3ALDH1A1HSD17B10CYP2A6
SCHEMBL16487392 0.68 HPRT1 (0.47) ALDH1A1HSD17B10TSHRHIF1ACYP2A6
SCHEMBL15302884 0.66 ALDH1A1 (0.43) ALDH1A1HSD17B10TSHRHIF1ACYP2A6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9260458-B2 Method of producing an organic silicon compound DOW CORNING CORPORATION (US) 2016-02-16 US disclosed
US-20150141689-A1 Method Of Producing An Organic Silicon Compound DOW TORAY CO., LTD. (JP) 2015-05-21 US disclosed
EP-2797855-A1 METHOD OF PRODUCING AN ORGANIC SILICON COMPOUND Dow Corning Toray Co., Ltd. (JP) 2014-11-05 EP disclosed
WO-2013100166-A1 METHOD OF PRODUCING AN ORGANIC SILICON COMPOUND DOW CORNING TORAY CO., LTD. (JP) 2013-07-04 WO disclosed