Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPB1 | P04792 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15770914 | 0.96 | HSPB1 (0.51) | HSPB1TDP1L3MBTL1MAPTGAA | |
| SCHEMBL26631827 | 0.86 | MAPT (0.46) | TDP1L3MBTL1MAPTGAAHTT | |
| SCHEMBL26631738 | 0.86 | MAPT (0.43) | HSPB1TDP1L3MBTL1MAPTGAA | |
| SCHEMBL15067230 | 0.83 | HSPB1 (0.54) | HSPB1TDP1L3MBTL1MAPTGAA | |
| SCHEMBL20155384 | 0.82 | HSPB1 (0.53) | HSPB1TDP1L3MBTL1MAPTGAA | |
| SCHEMBL26631729 | 0.80 | ALDH1A1 (0.46) | TDP1L3MBTL1MAPTHTTMEN1 | |
| SCHEMBL29634822 | 0.79 | HPGD (0.52) | TDP1L3MBTL1MAPTMEN1POLB | |
| SCHEMBL28496978 | 0.79 | HSPB1 (0.60) | HSPB1TDP1L3MBTL1MAPTGAA | |
| SCHEMBL16046439 | 0.78 | HSPB1 (0.66) | HSPB1TDP1L3MBTL1MAPTGAA | |
| SCHEMBL16049146 | 0.78 | HSPB1 (0.62) | HSPB1TDP1L3MBTL1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013828-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| EP-3013827-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014206345-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2014-12-31 | — | — | WO | disclosed |
| WO-2014206150-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2014-12-31 | — | — | WO | disclosed |
| EP-2797918-A1 | BROMODOMAIN INHIBITORS | AbbVie Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097601-A1 | BROMODOMAIN INHIBITORS | ABBVIE INC. (US) | 2013-07-04 | — | — | WO | disclosed |