Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26631729 | 0.89 | ALDH1A1 (0.46) | TDP1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL29634821 | 0.83 | SMN1; SMN2 (0.45) | TDP1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL87462 | 0.81 | TDP1 (0.77) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL15770914 | 0.81 | HSPB1 (0.51) | TDP1MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL15972175 | 0.80 | POLB (0.51) | TDP1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL26631738 | 0.80 | MAPT (0.43) | HPGDTDP1LMNAMEN1KMT2A | |
| SCHEMBL26631827 | 0.80 | MAPT (0.46) | TDP1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL15067957 | 0.79 | HSPB1 (0.47) | TDP1MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL31352860 | 0.77 | CTSV (0.50) | HPGDLMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL26113307 | 0.77 | CTSV (0.50) | HPGDLMNAMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4240489-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2023-09-13 | — | — | EP | disclosed |
| WO-2022098625-A1 | KRAS G12D INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-05-12 | — | — | WO | disclosed |