SCHEMBL15067969

SCHEMBL15067969

CS(=O)(=O)c1ccc(Oc2ccc(F)cc2F)c(I)c1

nearest known ligand 0.56

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 3/20 0.56
PTGS1 P23219 2/20 0.56
BRD4 O60885 13/20 0.55
EPAS1 Q99814 1/20 0.49
BRD2 P25440 2/20 0.48
BRD3 Q15059 2/20 0.48
BRDT Q58F21 2/20 0.48
TRIM24 O15164 1/20 0.48
BAZ2A Q9UIF9 1/20 0.48
CREBBP Q92793 1/20 0.47
SLC6A4 P31645 1/20 0.45
MAPK14 Q16539 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30498824 1.00 PTGS2 (0.56) PTGS2PTGS1BRD4EPAS1BRD2
SCHEMBL15068172 0.85 EPAS1 (0.52) PTGS2PTGS1BRD4EPAS1
SCHEMBL20155456 0.84 PTGS2 (0.61) PTGS2PTGS1BRD4EPAS1BRD2
SCHEMBL30306252 0.82 EPAS1 (0.71) PTGS2PTGS1BRD4EPAS1BRD2
SCHEMBL16651328 0.82 EPAS1 (0.71) PTGS2PTGS1BRD4EPAS1BRD2
SCHEMBL15067648 0.82 PTGS2 (0.56) PTGS2PTGS1BRD4EPAS1BRD2
SCHEMBL30693774 0.79 HSPB1 (0.67) PTGS2PTGS1BRD4BRD2BRD3
SCHEMBL15067482 0.79 HSPB1 (0.67) PTGS2PTGS1BRD4BRD2BRD3
SCHEMBL30498839 0.78 PTGS2 (0.46) PTGS2PTGS1BRD4EPAS1SLC6A4
SCHEMBL9656894 0.78 PTGS2 (0.58) PTGS2PTGS1BRD4EPAS1BRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250109132-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA DESIGN THERAPEUTICS INC (US) 2025-04-03 US disclosed
EP-4460302-A2 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2024-11-13 EP disclosed
US-20240124491-A1 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. 2024-04-18 US disclosed
EP-4274583-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2023-11-15 EP disclosed
WO-2023133284-A2 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2023-07-13 WO disclosed
WO-2023133284-A2 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2023-07-13 WO disclosed
US-20230158039-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2023-05-25 US disclosed
WO-2022150555-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2022-07-14 WO disclosed
WO-2022150555-A2 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA Design Therapeutics, Inc. (US) 2022-07-14 WO disclosed
US-20210236508-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2021-08-05 US disclosed
US-20160185769-A1 Bromodomain Inhibitors ABBVIE INC. (US) 2016-06-30 US disclosed
US-20160143916-A1 BROMODOMAIN INHIBITORS ABBVIE INC (US) 2016-05-26 US disclosed
EP-3013828-A1 BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2016-05-04 EP disclosed
EP-3013827-A1 BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2016-05-04 EP disclosed
US-9296741-B2 Bromodomain inhibitors ABBVIE INC. (US) 2016-03-29 US disclosed
WO-2014206345-A1 BROMODOMAIN INHIBITORS ABBVIE INC. (US) 2014-12-31 WO disclosed
WO-2014206150-A1 BROMODOMAIN INHIBITORS ABBVIE INC. (US) 2014-12-31 WO disclosed
EP-2797918-A1 BROMODOMAIN INHIBITORS AbbVie Inc. (US) 2014-11-05 EP disclosed
US-20140162971-A1 BROMODOMAIN INHIBITORS ABBVIE INC. 2014-06-12 US disclosed
WO-2013097601-A1 BROMODOMAIN INHIBITORS ABBVIE INC. (US) 2013-07-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124491-A1 METHODS AND COMPOUNDS FOR TREATING FRIEDREICH'S ATAXIA ATXN2, ATXN2L, CDR2 PTGS2 3557/4885PTGS1 3878/4885BRD4 742/4885
US-20140162971-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 PTGS2 1807/4885PTGS1 450/4885BRD4 1/4885
US-20230158039-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 PTGS2 1807/4885PTGS1 450/4885BRD4 1/4885
US-20250109132-A1 COMPOUNDS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA ATXN2, ATXN2L, ATXN10 PTGS2 3641/4885PTGS1 3864/4885BRD4 620/4885
US-20160185769-A1 Bromodomain Inhibitors BRD1, BRD4, BRD3 PTGS2 2097/4885PTGS1 401/4885BRD4 2/4885
US-20160143916-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 PTGS2 1807/4885PTGS1 450/4885BRD4 1/4885
US-20210236508-A1 BROMODOMAIN INHIBITORS BRD4, BRD1, BRD3 PTGS2 1807/4885PTGS1 450/4885BRD4 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.