Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15065405 | 0.96 | LMNA (0.46) | LMNAHTR1ADRD2IKBKBHSD17B10 | |
| SCHEMBL15065524 | 0.85 | ALDH1A1 (0.45) | LMNAIKBKBHSD17B10TNFRSF1AERN1 | |
| SCHEMBL15064637 | 0.81 | HSD17B10 (0.45) | LMNAHTR1ADRD2IKBKBHSD17B10 | |
| SCHEMBL15064633 | 0.81 | HSD17B10 (0.45) | LMNAHTR1ADRD2IKBKBHSD17B10 | |
| SCHEMBL15066001 | 0.81 | ALDH1A1 (0.46) | LMNAERN1ALDH1A1POLBKDM4E | |
| SCHEMBL15065527 | 0.80 | HTR1A (0.55) | LMNAHTR1ADRD2HSD17B10ALDH1A1 | |
| SCHEMBL29477092 | 0.80 | HTR1A (0.55) | LMNAHTR1ADRD2HSD17B10ALDH1A1 | |
| SCHEMBL29538704 | 0.79 | LRRK2 (0.50) | LMNAHTR1ADRD2IKBKBHSD17B10 | |
| SCHEMBL15066252 | 0.79 | ALDH1A1 (0.41) | LMNAHTR1AERN1ALDH1A1KDM4E | |
| SCHEMBL30078164 | 0.78 | MRGPRX4 (0.59) | HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797597-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | Global Blood Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013102145-A1 | SUBSTITUTED HETEROARYL ALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |