Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.73 |
| ▸ | NPC1 | O15118 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.73 |
| ▸ | PKM | P14618 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15066680 | 0.81 | RAB9A (0.71) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15068561 | 0.79 | NPC1 (0.47) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15067282 | 0.78 | NPC1 (0.46) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL4726437 | 0.77 | RAB9A (0.71) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15066061 | 0.77 | ALDH1A1 (1.00) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15068657 | 0.77 | NPC1 (0.44) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15068977 | 0.76 | SUV39H2 (0.45) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15066084 | 0.75 | NPC1 (0.43) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15066786 | 0.74 | ALDH1A1 (0.64) | RAB9ANPC1ALDH1A1MAPTPKM | |
| SCHEMBL15068496 | 0.74 | RAB9A (0.57) | RAB9ANPC1ALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797592-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |