Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 5/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15068776 | 1.00 | NPC1 (0.38) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL15068551 | 1.00 | NPC1 (0.38) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL30708172 | 1.00 | NPC1 (0.38) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL15069027 | 0.91 | NPC1 (0.37) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL15068856 | 0.91 | NPC1 (0.37) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL27262304 | 0.91 | NPC1 (0.37) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL21301319 | 0.91 | NPC1 (0.37) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL21324749 | 0.91 | NPC1 (0.37) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL21301234 | 0.91 | NPC1 (0.37) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL15068502 | 0.91 | NPC1 (0.38) | NPC1RAB9AALDH1A1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4743087-A1 | METHODS FOR COMBINATION TREATMENT OF SPINAL MUSCULAR ATROPHY | Epirium Bio Inc. (US) | 2026-05-20 | — | — | EP | claimed |
| WO-2025019367-A1 | METHODS FOR COMBINATION TREATMENT OF SPINAL MUSCULAR ATROPHY | EPIRIUM BIO INC. (US) | 2025-01-23 | — | — | WO | claimed |
| US-RE47689-E1 | Compounds for treating spinal muscular atrophy | PTC THERAPEUTICS, INC. (US) | 2019-11-05 | — | — | US | claimed |
| EP-2797592-B1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2019-08-28 | — | — | EP | claimed |
| US-9617268-B2 | Compounds for treating spinal muscular atrophy | PTC THERAPEUTICS, INC. (US) | 2017-04-11 | — | — | US | claimed |
| WO-2015095449-A1 | METHODS FOR MODULATING THE AMOUNT RNA TRANSCRIPTS | PTC THERAPEUTICS, INC. (US) | 2015-06-25 | — | — | WO | claimed |
| US-20150119380-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-30 | — | — | US | claimed |
| EP-2797592-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC Therapeutics, Inc. (US) | 2014-11-05 | — | — | EP | claimed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | claimed |
| EP-4743087-A1 | METHODS FOR COMBINATION TREATMENT OF SPINAL MUSCULAR ATROPHY | Epirium Bio Inc. (US) | 2026-05-20 | — | — | EP | disclosed |
| EP-4729069-A1 | USE OF ANTI-PRO/LATENT MYOSTATIN ANTIBODY FOR TREATING SPINAL MUSCULAR ATROPHY | Scholar Rock, Inc. (US) | 2026-04-22 | — | — | EP | disclosed |
| EP-4724585-A1 | INDUCIBLE GENE EXPRESSION SYSTEM | F. Hoffmann-La Roche AG (CH) | 2026-04-15 | — | — | EP | disclosed |
| EP-4518970-B1 | USE OF MYOSTATIN INHIBITOR FOR TREATING SPINAL MUSCULAR ATROPHY | SCHOLAR ROCK INC (US) | 2026-03-25 | — | — | EP | disclosed |
| EP-4218804-B1 | USE OF MYOSTATIN INHIBITORS AND COMBINATION THERAPIES | SCHOLAR ROCK INC (US) | 2026-01-21 | — | — | EP | disclosed |
| WO-2015095449-A1 | METHODS FOR MODULATING THE AMOUNT RNA TRANSCRIPTS | PTC THERAPEUTICS, INC. (US) | 2015-06-25 | — | — | WO | disclosed |
| US-20150164901-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING NEURODEGENERATIVE DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-06-18 | — | — | US | disclosed |
| US-20150164901-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING NEURODEGENERATIVE DISORDERS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2015-06-18 | — | — | US | disclosed |
| US-20150119380-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-30 | — | — | US | disclosed |
| US-20150119380-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | F. HOFFMANN-LA ROCHE AG (CH) | 2015-04-30 | — | — | US | disclosed |
| WO-2013101974-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS, INC. (US) | 2013-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150119380-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | SMN1; SMN2, RBM17, RBM22 | NPC1 4329/4885RAB9A 3292/4885ALDH1A1 1006/4885 |
| US-20150164901-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING NEURODEGENERATIVE DISORDERS | SMN1; SMN2, SOD1, SNCA | NPC1 484/4885RAB9A 1358/4885ALDH1A1 1673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.