Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.55 |
| ▸ | NOS1 | P29475 | 4/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8666610 | 0.84 | NOS1 (0.57) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL27623287 | 0.80 | MAPK1 (0.48) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL27885403 | 0.78 | MAPK1 (0.51) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL8220180 | 0.78 | ROCK2 (0.54) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL27998026 | 0.78 | MAPK1 (0.56) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL27995718 | 0.78 | NOS1 (0.55) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL6585051 | 0.77 | ROCK2 (0.58) | MAPK1NOS1ROCK2ROCK1MAPT | |
| SCHEMBL25205712 | 0.76 | MAPK1 (0.55) | MAPK1ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL30564484 | 0.76 | MAPK1 (0.55) | MAPK1ROCK2ROCK1MEN1KMT2A | |
| SCHEMBL9223010 | 0.75 | ROCK2 (0.50) | MAPK1NOS1ROCK2ROCK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2797889-A1 | NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | Centaurus Biopharma Co., Ltd. (CN) | 2014-11-05 | — | — | EP | disclosed |
| WO-2013097773-A1 | NOVEL ARYLALKENE DERIVATIVES AND USE THEREOF AS SELECTIVE ESTROGEN RECEPTOR MODULATORS | CENTAURUS BIOPHARMA CO., LTD. (CN) | 2013-07-04 | — | — | WO | disclosed |