Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.54 |
| ▸ | GSK3B | P49841 | 4/20 | 0.54 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.54 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.54 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | GSK3A | P49840 | 1/20 | 0.54 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.54 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.54 |
| ▸ | NOS1 | P29475 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | METAP2 | P50579 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223010 | 0.90 | ROCK2 (0.50) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL8666610 | 0.89 | NOS1 (0.57) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL14402704 | 0.88 | GRIN2B (0.48) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL28495876 | 0.87 | GRIN2B (0.47) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL9228354 | 0.87 | GRIN2B (0.47) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL9228890 | 0.86 | MAPT (0.50) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL764032 | 0.85 | CDC7 (0.55) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL27885403 | 0.82 | MAPK1 (0.51) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL27995718 | 0.82 | NOS1 (0.55) | ROCK2GSK3BPIM1ROCK1JAK2 | |
| SCHEMBL27998026 | 0.82 | MAPK1 (0.56) | ROCK2GSK3BPIM1ROCK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017160361-A1 | POLYISOCYANURATE CATALYSTS FOR METAL PANELS AND SPRAY FOAMS | HUNTSMAN PETROCHEMICAL LLC (US) | 2017-09-21 | — | — | WO | claimed |
| US-20230312481-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | ARBUTUS BIOPHARMA CORP (CA) | 2023-10-05 | — | — | US | disclosed |
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| US-11078233-B2 | Tripeptide epoxy ketone protease inhibitors | ONYX THERAPEUTICS, INC. (US) | 2021-08-03 | — | — | US | disclosed |
| US-10034879-B2 | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20180117040-A1 | SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | GLOBAL BLOOD THERAPEUTICS, INC. | 2018-05-03 | — | — | US | disclosed |
| WO-2017160361-A1 | POLYISOCYANURATE CATALYSTS FOR METAL PANELS AND SPRAY FOAMS | HUNTSMAN PETROCHEMICAL LLC (US) | 2017-09-21 | — | — | WO | disclosed |
| EP-2970224-B1 | TRIPEPTIDE EPOXY KETONE PROTEASE INHIBITORS | ONYX THERAPEUTICS INC (US) | 2017-09-06 | — | — | EP | disclosed |
| US-9718815-B2 | Heterocyclic compounds and uses thereof | INFINITY PHARMACEUTICALS, INC. (US) | 2017-08-01 | — | — | US | disclosed |
| US-9682141-B2 | Combination of kinase inhibitors and uses thereof | INTELLIKINE LLC (US) | 2017-06-20 | — | — | US | disclosed |
| US-5376152-A | Heterocyclic nitrogen compound mannich base derivatives of polyolefin-substituted amines for oleaginous compositions | EXXON CHEMICAL PATENTS INC. (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0518949-B1 | NOVEL HETEROCYCLIC NITROGEN COMPOUND MANNICH BASE DERIVATIVES OF AMINO-SUBSTITUTED POLYMERS FOR OLEAGINOUS COMPOSITIONS | EXXON CHEMICAL PATENTS INC (US) | 1994-06-22 | — | — | EP | disclosed |
| US-5273671-A | Reaction product of ethylene/alpha-olefin copolymer, polyamine, aldehyde and a benzotriazole or benzimidazole | EXXON CHEMICAL PATENTS INC. (US) | 1993-12-28 | — | — | US | disclosed |
| US-5271856-A | Heterocyclic nitrogen compound Mannich base derivatives of amino-substituted polymers for oleaginous compositions | EXXON CHEMICAL PATENTS INC. (US) | 1993-12-21 | — | — | US | disclosed |
| US-5232615-A | Reacting an amine with halogenated polyolefin to form adduct and contacting adduct with an aldehyde and a heterocyclic reactant to form an oil soluble, oxidation resistance dispersant for fuels | EXXON CHEMICAL PATENTS INC. (US) | 1993-08-03 | — | — | US | disclosed |
| US-5211865-A | Oil soluble ethylene copolymer with alpha-olefin and grafted carboxylic acid and anhydride with polyamine, an anhydride and heterocycle | EXXON CHEMICAL PATENTS INC. (US) | 1993-05-18 | — | — | US | disclosed |
| EP-0520012-A1 | IMPROVED MULTIFUNCTIONAL VISCOSITY INDEX IMPROVER-DISPERSANT ANTIOXIDANT (PT-789). | EXXON CHEMICAL PATENTS INC (US) | 1992-12-30 | — | — | EP | disclosed |
| EP-0518949-A1 | NOVEL HETEROCYCLIC NITROGEN COMPOUND MANNICH BASE DERIVATIVES OF AMINO-SUBSTITUTED POLYMERS FOR OLEAGINOUS COMPOSITIONS. | EXXON CHEMICAL PATENTS INC (US) | 1992-12-23 | — | — | EP | disclosed |
| WO-1991013952-A1 | IMPROVED MULTIFUNCTIONAL VISCOSITY INDEX IMPROVER-DISPERSANT ANTIOXIDANT (PT-789) | EXXON CHEMICAL PATENTS INC. (US) | 1991-09-19 | — | — | WO | disclosed |
| WO-1991013954-A1 | NOVEL HETEROCYCLIC NITROGEN COMPOUND MANNICH BASE DERIVATIVES OF AMINO-SUBSTITUTED POLYMERS FOR OLEAGINOUS COMPOSITIONS | EXXON CHEMICAL PATENTS INC. (US) | 1991-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11078233-B2 | Tripeptide epoxy ketone protease inhibitors | PREP, CTRL, ENPEP | ROCK2 2433/4885GSK3B 1401/4885PIM1 1329/4885 |
| US-10034879-B2 | Substituted benzaldehyde compounds and methods for their use in increasing tissue oxygenation | HBB, HBG2, MB | ROCK2 2039/4885GSK3B 1432/4885PIM1 984/4885 |
| US-20230312481-A1 | SUBSTITUTED (PHTHALAZIN-1-YLMETHYL)UREAS, SUBSTITUTED N-(PHTHALAZIN-1-YLMETHYL)AMIDES, AND ANALOGUES THEREOF | NSD3, PML, NSD1 | ROCK2 4478/4885GSK3B 2563/4885PIM1 3270/4885 |
| US-20180117040-A1 | SUBSTITUTED BENZALDEHYDE COMPOUNDS AND METHODS FOR THEIR USE IN INCREASING TISSUE OXYGENATION | HBB, HBG2, MB | ROCK2 2039/4885GSK3B 1432/4885PIM1 984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.