Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | HTR2A | P28223 | 6/20 | 0.44 |
| ▸ | HTR2B | P41595 | 6/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27343433 | 0.85 | HTR2C (0.49) | HTR2CHTR2AHTR2BKDM1ASRD5A1 | |
| SCHEMBL28823682 | 0.77 | HTR2C (0.43) | HTR2CHTR2AHTR2BKDM1ASRD5A1 | |
| SCHEMBL27919507 | 0.73 | HTR2C (0.50) | HTR2CHTR2AHTR2BKDM1APNMT | |
| SCHEMBL31579647 | 0.70 | HTR2A (0.61) | HTR2CHTR2AHTR2BKDM1AADRB1 | |
| SCHEMBL6159366 | 0.70 | HTR2A (0.61) | HTR2CHTR2AHTR2BKDM1AADRB1 | |
| SCHEMBL27818616 | 0.70 | CA1 (0.50) | KDM1ASLC6A9 | |
| SCHEMBL27975547 | 0.69 | PNMT (0.41) | HTR2CHTR2AHTR2BSRD5A1PNMT | |
| SCHEMBL15568933 | 0.69 | TSHR (0.60) | HTR2CHTR2AHTR2BKDM1ASRD5A1 | |
| SCHEMBL15071424 | 0.69 | ALDH1A1 (0.52) | HTR2CHTR2AHTR2BKDM1AOPRM1 | |
| SCHEMBL8222482 | 0.67 | PRCP (0.67) | HTR2CHTR2AKDM1APRCP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013096150-A1 | SUBSTITUTED PIPERIDINES AS HDM2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-06-27 | — | — | WO | disclosed |