Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | SRD5A1 | P18405 | 4/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27343433 | 0.91 | HTR2C (0.49) | HTR2CHTR2AHTR2BSRD5A1PNMT | |
| SCHEMBL28823708 | 0.82 | CAMK2A (0.47) | HTR2CHTR2AHTR2BSRD5A1PNMT | |
| SCHEMBL27975547 | 0.81 | PNMT (0.41) | HTR2CHTR2AHTR2BSRD5A1PNMT | |
| SCHEMBL28823725 | 0.81 | LRRK2 (0.42) | PNMTKDM1A | |
| SCHEMBL28823672 | 0.79 | HTR2C (0.49) | HTR2CHTR2AHTR2BSRD5A1KDM1A | |
| SCHEMBL27919507 | 0.78 | HTR2C (0.50) | HTR2CHTR2AHTR2BPNMTKDM1A | |
| SCHEMBL28967711 | 0.78 | PRCP (0.42) | HTR1AADRA2A | |
| SCHEMBL15071404 | 0.77 | HTR2C (0.44) | HTR2CHTR2AHTR2BSRD5A1PNMT | |
| SCHEMBL28823799 | 0.76 | PPARD (0.41) | HTR2C | |
| SCHEMBL28823734 | 0.76 | CA1 (0.50) | SLC6A2SLC6A4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114929691-A | Bicyclic compounds and uses thereof | 爱思开生物制药株式会社 | 2022-08-19 | — | — | CN | disclosed |